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ProteomicsEstablishment of goat mammary organoid cultures modeling the mammary gland development and lactation
The lactating mammary glands in ruminants play a pivotal economic role in agriculture and food nutrition. The need for an improved 3D in vitro model to study its lactating biology highlights the importance of ongoing research in this field. Overcoming these challenges represents a crucial area of ...
ORGANISM(S): Capra hircus (Goat) 
2025-05-06 | PXD050745 | Pride
Dia Mammary organoids Dairy goat 
TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
TranscriptomicsTargeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment
Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3 alleles in ErbB3FL/FL were cultured in the presence or absence of doxycycline to induce ErbB3 loss. The gene expression shift following DOX-induce...
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-32129 | biostudies-arrayexpress
TranscriptomicsECM-dependent gene expression in normal and tumor-derived mammary organoids
A critical step in metastasis is cancer cell dissemination. Dissemination and metastasis are associated with specific genetic changes and changes in extracellular matrix (ECM), but how these changes interact to enable dissemination remains unclear. Here we tested the importance of ECM to disseminat...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-39173 | biostudies-arrayexpress
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40702 | biostudies-arrayexpress
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (RT_PCR)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40704 | biostudies-arrayexpress
GenomicsA living biobank of breast cancer organoids captures disease heterogeneity
Breast Cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Xeno-transplantation and direct culturing of tumor tissue are increasingly used in drug development and personalized medicine strategies. Here, we describe a robust protocol for long-term...
EGAS00001002158 | EGA
TranscriptomicsTranscription profiling of mouse normal mammary gland epithelial populations: basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells
The goal of the experiment was to carry out a transcriptome analysis of the three main epithelial cell populations of the mouse mammary gland, the basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells, to identify cell-type specific differen...
ORGANISM(S): Mus musculus 
2009-04-20 | E-TABM-683 | biostudies-arrayexpress
ProteomicsMouse mammary gland epithelial organoids
This submission contains the mass spectrometry files for the manuscript by Aurelie Lacouture et al. that describes the quantitative proteomics analysis of mouse mammary gland epithelial organoids proteome. Experiments were performed from mammary glands organoids derived from mouse and the MS files w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-12-01 | MSV000100067 | MassIVE
UnknownOptimal, Large-Scale Propagation of Mouse Mammary Tumor Organoids.
Not available
S-EPMC7587543 | biostudies-literature
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