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MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsRoles for microRNAs, miR-93 and miR-130b, and TP53INP1 tumor suppressor in cell growth dysregulation by HTLV-1
This is to study the role of miRNAs in human T-cell leukemia virus-1, HTLV-1. In this study, we profiled the miRNA expression in virus transformed human cell lines and primary peripheral blood mononuclear cells (PBMCs) from Adult-T cell leukemia (ATL) patients using the RNA-primed, array-based Kleno...
ORGANISM(S): Homo sapiens 
2008-06-06 | E-GEOD-11577 | biostudies-arrayexpress
TranscriptomicsInositol regulation with Cryptococcus neoformans JEC21 70-mer whole genome array
Cryptococcus neoformans is the most common cause of fungal meningitis, with high mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in the central nervous system (CNS) is poorly understood. In this study, we find that inositol plays an important role in the tra...
ORGANISM(S): Cryptococcus neoformans 
2012-09-29 | E-GEOD-41211 | biostudies-arrayexpress
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fibroblast cells transfected with zinc-inducible C/EBP expression vectors identifies Per2 as a gene implicated in myeloid leukemia
The zinc-inducible C/EBP expression vectors pMTa, pMTb, pMTd and pMTe were constructed by cloning the human C/EBPa, C/EBPb, C/EBPd and C/EBPe cDNAs, respectively, into the pMTCB6+ vector. NIH 3T3 cells were transfected with zinc-inducible C/EBP vectors as well as control empty vector using the GeneP...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2188 | biostudies-arrayexpress
TranscriptomicsKetamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles
Background: Examining transcriptional regulation by existing antidepressants in key neural circuits implicated in depression, and understanding the relationship to transcriptional mechanisms of susceptibility and natural resilience, may help in the search for new therapeutics. Further, given the het...
ORGANISM(S): Mus musculus 
2016-07-27 | E-GEOD-81672 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with sulforaphane (SF)
Effect of sulforaphane (SF) on human colon caco-2 cells after 24h treatment
ORGANISM(S): Homo sapiens 
2005-07-01 | E-MEXP-170 | biostudies-arrayexpress
TranscriptomicsMolecular Evidence for a Dimensional Basis of Depression
Here we identified a set of genes with frequent expression changes in the postmortem brain of MDD subjectsand show that this gene set is genetically related to brain and organ illnesses frequently associated with MDD. Specifically, we performed a meta-analysis of eight gene array studies in three co...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-44593 | biostudies-arrayexpress
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