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Transcriptomicspoly(A) specific ribonuclease (PARN)-dependent trimming of H ACA box RNAs
Microarray comprising probe sets for miRNAs and other small RNAs was used to determine which and how many small RNAs are potential substrates of poly(A) specific ribonuclease (PARN) in U2OS cells . Hybridization probes were generated by oligo(dT) priming.
ORGANISM(S): Homo sapiens 
2012-02-17 | E-MEXP-3344 | biostudies-arrayexpress
TranscriptomicsA Systematic Substrate Screen Links Cyclin D-Dependent Kinases to Senescence Suppression in Cancer Cells through FOXM1
Gene expression (mRNA profiling) of U2OS osteosarcoma cells treated with 1 mM of the CDK4/6-specific inhibitor, PD0332991, versus vehicle (DMSO) for 4 hours Here, we monitored the early transcriptional response to acute inhibition of CDK4/6 catalytic activity. As PD0332991 substantially induced sene...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-32182 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Exposure Phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36465 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Recovery phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36466 | biostudies-arrayexpress
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
TranscriptomicsDiscovery of genes regulated by the metastasis suppressor gene, RhoGDI2
A number of studies find that metastasis suppressor proteins, including RhoGDI2, may function in part though controlling expression of genes regulating metastasis (reviewed in Smith and Theodorescu, Nature Reviews Cancer, 2009, PMID: 19242414). To uncover systematically gene expression patterns depe...
ORGANISM(S): Homo sapiens 
2012-04-14 | E-GEOD-35014 | biostudies-arrayexpress
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsVAP-mediated membrane tethering mechanisms implicate ER-PM contact function in pH homeostasis
MS analyses of interactome of full-length (i.e., Scs2 and Scs22) and TM-truncated (i.e., Scs2N and Scs22N) fission yeast VAPs.
ORGANISM(S): Schizosaccharomyces Pombe (fission Yeast) 
2024-08-09 | PXD053887 | JPOST Repository
TranscriptomicsmiRNA arrays for LPS-activated Akt1+/+ and Akt1-/- macrophages
MicroRNAs regulated by lipopolysaccharide (LPS) target genes that contribute to the inflammatory phenotype. Here we showed that the protein kinase Akt1, which is activated by LPS, positively regulated miRNAs let-7e, miR-181c but negatively regulated miR-155 and miR-125b. In silico analyses and trans...
ORGANISM(S): Mus musculus 
2009-08-21 | E-GEOD-17421 | biostudies-arrayexpress
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
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