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ProteomicsProteomic Atlas of the Human Brain in Alzheimer’s Disease
Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small var...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088398 | MassIVE
OtherA proteomics search algorithm specifically designed for high-resolution tandem mass spectra.
Data from the authors [[www.chem.wisc.edu/~coon/Downloads/Morpheus web site]]. Experiment: yeast cad, file: 2010-12-05_Yeast_Trypsin_IT_CAD_Rep4.mgf. Published as part of J Proteome Res. 2013 Mar 1;12(3):1377-86 [[http://www.ncbi.nlm.nih.gov/pubmed/23323968 PubMed]]. From the Abstract: {{i}} ... For...
ORGANISM(S): Yeast 
GPM11210018150 | GPMDB
ProteomicsEvaluation of Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics
The Orbitrap Ascend Tribrid mass spectrometer was systematically evaluated in the context of shotgun proteomics, and its performance was compared to that of the previous generation of Tribrid instrument - Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-03-10 | MSV000091467 | MassIVE
ProteomicsPRMT6 substrate specificity analysis
Protein arginine methyltransferase 6 (PRMT6) catalyses the asymmetric dimethylation of arginines on numerous substrate proteins within the human cell. In particular, PRMT6 methylates histone H3 arginine 2 (H3R2) which affects both gene repression and activation. However, the substrate specificity of...
ORGANISM(S): Homo Sapiens 
2021-03-31 | PXD016711 | panorama
ProteomicsMITOMICS: defining mitochondrial protein functions through deep multi-omic profiling
Mitochondria are epicenters of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to over 150 distinct disorders. However, hundreds of mitochondrial proteins still lack clea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-11 | MSV000086685 | MassIVE
ProteomicsRPL40 methyltransferase discovery and characterisation
The eukaryotic ribosome is highly modified by protein methylation, yet many of the responsible methyltransferases remain unknown. Here we have identified SMYD5 as a ribosomal protein methyltransferase that catalyses trimethylation of RPL40 at lysine 22. Through a systematic mass spectrometry-based a...
ORGANISM(S): Homo Sapiens 
2025-04-16 | PXD056489 | panorama
TranscriptomicsA functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease
Microarray Analysis of Human Whole Blood and Intestinal Biopsy Samples from a Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Crohn’s Disease 329 Crohn's biopsies from multiple regions in the intestine of 87 anti TNFa refractory patients an...
ORGANISM(S): Homo sapiens 
2017-07-07 | E-GEOD-100833 | biostudies-arrayexpress
ModelsCD4 T cell signaling
Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse ...
3521 | Cell Collective
ProteomicsNCLX proximity biotinylation screen
The mitochondrial sodium/calcium exchanger, NCLX, is critical to maintaining mitochondrial calcium homeostasis, yet little remains known about the mechanisms regulating its function. Here, we performed proximity biotinylation screening to identify the NCLX interactome and potential protein regulator...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000093004 | MassIVE
UnknownNivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Not available
S-EPMC8436591 | biostudies-literature
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