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Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
TranscriptomicsTranscription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation
Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress
TranscriptomicsExpression data comparing human DKK1 and control vector transfected murine osteochondrosarcoma cells (MOS-J)
Canonical Wnt signaling controls proliferation and differentiation of osteogenic progenitor cells, and tumor-derived secretion of the Wnt antagonist Dickkopf-1 (Dkk1) is correlated with osteolyses and metastasis in many bone malignancies. However, the role of Dkk1 in the oncogenesis of primary osteo...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-43112 | biostudies-arrayexpress
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
TranscriptomicsPRR7 is a novel NMDA-dependent inhibitor of c-Jun ubiquitination in neurons
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults such as stroke and epilepsy. NMDA receptor (NMDAR) antagonists block c-Jun upregulation and prevent neuronal cell death following excito...
ORGANISM(S): Rattus norvegicus 
2014-10-25 | E-GEOD-62686 | biostudies-arrayexpress
TranscriptomicsGlobal changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene
It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent tri...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-36359 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart tissue from rats that have undergone treadmill exercise or have been sedentary for different lengths of time
Seventy two rats were randomized to twelve independent groups of rats (n = 6 in all groups) where half of the rats were chosen for training (treadmill exercise training 1.5 hour 5 days a week, in 1, 4, 24, 48 days and for 4 and 8 weeks) or sedentary (no training) as described in detail by Wisloff et...
ORGANISM(S): Rattus norvegicus 
2006-11-10 | E-TABM-166 | biostudies-arrayexpress
TranscriptomicsCharacterization of the piRNA Complex from Rat Testes
This data series contains the sequences and read counts of Piwi-interacting RNAs and other small RNAs from mouse and rat testes extracts. In a search for different classes of small RNAs that might be involved in transcriptional gene silencing, we encountered a novel class of small RNAs within mamma...
ORGANISM(S): Mus musculus 
2006-07-02 | E-GEOD-5026 | biostudies-arrayexpress
UnknownTranscriptome-wide N6-methyladenosine modification and microRNA jointly regulate the infection of avian leukosis virus subgroup J in vitro.
Not available
S-EPMC10999702 | biostudies-literature
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