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TranscriptomicsHeterogeneous genetic profiles in soft tissue myoepitheliomas
Myoepithelioma, mixed tumor and parachordoma are rare soft tissue tumors thought to represent different morphologic variants of the same family of tumors, hereafter referred to as MMP tumors. The genetic basis of these neoplasms is poorly investigated. However, they morphologically resemble mixed tu...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10266 | biostudies-arrayexpress
TranscriptomicsChordoma_32k_1Mb
Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridization DNA copy number analysis of 21 fresh frozen chordoma biopsies, and the respective relapse in four of them, using 32k and 1Mb array CGH. All cases showed copy number al...
ORGANISM(S): Homo sapiens 
2008-01-24 | E-GEOD-9023 | biostudies-arrayexpress
TranscriptomicsDNA copy number analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions
DNA copy number analysis of myxoinflammatory fibroblastic sarcomas, and related lesions, using 32k BAC array CGH. All four cases analyzed with array CGH showed amplification of the region 86.30-87.74 Mb in 3p11.1-12.1. No additional aberration was detected in more than two tumors, except for the del...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-12593 | biostudies-arrayexpress
TranscriptomicsConcomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-19040 | biostudies-arrayexpress
TranscriptomicsRetained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma (Illumina)
Inflammatory leiomyosarcoma (ILMS) is a soft tissue tumor that morphologically resembles conventional leiomyosarcoma (LMS) admixed with a prominent inflammatory infiltrate. Genetic data on ILMS are still limited but have suggested that this entity is characterized by hyperhaploidy (24-34 chromosomes...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-38015 | biostudies-arrayexpress
TranscriptomicsTwo genetic pathways in myxoinflammatory fibroblastic sarcoma and morphologically similar lesions
This SuperSeries is composed of the following subset Series: GSE12592: Gene expression analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions GSE12593: DNA copy number analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions Refer to in...
ORGANISM(S): Homo sapiens 
2009-01-25 | E-GEOD-12595 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors (BAC/CGH)
DNA copy number analysis of 67 fresh frozen chondrosarcoma biopsies using 32k BAC and 244k oligo array CGH. Genomic imbalances, in most tumors affecting large regions of the genome, were found in 90% of the cases. Although rare, recurrent amplifications were found at 8q24.21-q24.22 and 11q22.1-q22.3...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-12439 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors (Illumina)
Gene expression profiling of 17 fresh frozen chondrosarcoma biopsies using the Human-6 v2 Expression BeadChip (Illumina Inc., San Diego, CA, USA). DNA copy number analyses was also performed in these tumors. Keywords: chondrosarcoma, gene expression profiling, Illumina Samples displaying a tumor co...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-12475 | biostudies-arrayexpress
TranscriptomicsRetained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma (Expression)
Global gene expression analysis of inflammatory leiomyosarcoma (ILMS) and conventional leiomyosarcoma (LMS). RNA was extracted from frozen tumor biopsies (3 ILMS and 15 LMS) and hybridized onto Affymetrix Human Gene 1.0 ST arrays. LMS_18b is the same sample as LMS_18a, analyzed at a different time p...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-37992 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions
Global gene expression analysis was performed in cases 1, 2, 5, 6 and 8 as well as in five pooled myxofibrosarcomas using the Affymetrix GeneChip Human Gene 1.0 ST Arrays (Affymetrix Inc., Santa Clara, CA, USA). Unsupervised hierarchical clustering analysis, using Pearson correlation and average lin...
ORGANISM(S): Homo sapiens 
2009-01-25 | E-GEOD-12592 | biostudies-arrayexpress
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