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TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsA predictive and prognostic 38-gene expression signature for metastatic relapse in breast cancer
Background Currently, no gene-expression signature (GES) established from node-positive cohorts, able to predict breast cancer evolution after systemic adjuvant chemotherapy, exists. Methods Gene-expression profiles of 252 node-positive patients (median follow-up: 7.7 years), mostly included in a ra...
ORGANISM(S): Homo sapiens 
2008-11-27 | E-GEOD-11264 | biostudies-arrayexpress
TranscriptomicsmiRNA chronic OVA aerosol
specific pathogen-free female BALB/c mice aged 7-8 weeks (Animal Resources Centre, Perth, Western Australia) were systemically sensitised by intraperitoneal injection of 50 M-5g of alum-precipitated chicken egg OVA (Grade V, ?98% pure, Sigma Australia) 21 and 7 days before inhalational challenge, th...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3118 | biostudies-arrayexpress
ProteomicsNCLX proximity biotinylation screen
The mitochondrial sodium/calcium exchanger, NCLX, is critical to maintaining mitochondrial calcium homeostasis, yet little remains known about the mechanisms regulating its function. Here, we performed proximity biotinylation screening to identify the NCLX interactome and potential protein regulator...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000093004 | MassIVE
TranscriptomicsGenome-wide analysis of monocyte derived macrophages from Crohn's Disease patients and controls
Crohn's disease (CD) is a complex and highly heterogeneous chronic inflammatory disorder, primarily affecting the gastrointestinal tract. Genetic and functional studies have highlighted a key role for innate immunity in its pathogenesis. Profound systemic defects in innate immunity and acute inflamm...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-60083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of monocytes derived from tolerant (Sahiwals, Bos indicus) and susceptible (Holstein-Friesians, Bos taurus) cattle to in vitro infection with Theileria annulata
Tropical theileriosis in a cattle disease of global economic importance, caused by the tick-borne protozoan parasite Theileria annulata. Conventional control strategies are failing to contain the disease and an attractive alternative is the use of pre-existing genetic resistance or tolerance. Howe...
ORGANISM(S): Bos taurus 
2007-04-26 | E-MAXD-25 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine monocytes stimulated with with interferon-g and lipopolysaccharide for 2 or 16 hours to validate a bovine macrophage specific cDNA microarray
Background The response of macrophages to danger signals is an important early stage in the immune response. Our understanding of this complex event has been furthered by microarray analysis, which allows the simultaneous investigation of the expression of large numbers of genes. However, the mic...
ORGANISM(S): Bos indicus 
2006-09-20 | E-MAXD-16 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Ovis aries Iymph node and spleen from animals infected by brain homogenate.
Spleen samples from five sheep (3 diseased and 2 control) were used on 10 chips.
Lymph node samples from five sheep (3 diseased and 2 control) were used on 10 chips.
ORGANISM(S): Ovis aries 
2010-04-01 | E-MEXP-2565 | biostudies-arrayexpress
TranscriptomicsPharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Withaferin A isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied in epithelial-l...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-53049 | biostudies-arrayexpress
UnknownA syndromic neurodevelopmental disorder caused by rare variants in PPFIA3.
Not available
S-EPMC10806447 | biostudies-literature
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