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TranscriptomicsComparative transcriptome analysis of Saccharomyces cerevisiae wild type and M-NM-^Tasc1 strain
Asc1p and its essential orthologues in higher eukaryotes, as e.g. RACK1 in mammals, are involved in several distinct cellular signaling processes, but the implications of a total deletion have never been assessed in a comprehensive genome-wide manner. This study reveals the major cellular processes ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-30 | E-GEOD-34286 | biostudies-arrayexpress
TranscriptomicsHeterochromatin protein 1 secures survival and transmission of malaria parasites
The malaria parasite Plasmodium falciparum relies on clonally variant gene expression in order to escape immune recognition and secure continuous proliferation during blood stage infection. Here, we studied the role of heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable...
ORGANISM(S): Plasmodium falciparum 3D7 
2014-07-09 | E-GEOD-53176 | biostudies-arrayexpress
TranscriptomicsDefective removal of ribonucleotides from DNA promotes systemic autoimmunity
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signalin...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63755 | biostudies-arrayexpress
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