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ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080865 | MassIVE
ProteomicsFoxp3+ regulatory T cells control hypothalamic inflammation
The central nervous system (CNS) hypothalamus controls systemic metabolism. Inflammatory CNS processes evolving upon exposure to calorie-rich diet are thought to promote impaired metabolic CNS control, thereby triggering obesity and Type-2 diabetes (T2D). However, immune cells relevant for maintaini...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-20 | PXD004498 | Pride
Hypothalamic inflammation T cells Lc-ms/ms 
ProteomicsAmyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Here, we combine cryo-electron tomography, proteomics and cell biology studies to investigate the effects of protein aggregates in primary neurons. We use artificial amyloid-like β-sheet proteins (β proteins) to focus on the gain-of-function aspect of aggregation. These proteins form fibrillar aggre...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-20 | PXD029689 | Pride
Neurons Toxic proteins Protein aggregates Neurodegeneration 
UnknownCryoEM single particle analysis of 65 kDa human haemoglobin using a 200 kV Talos Arctica
Not available
EMPIAR-10721 | biostudies-other
UnknownCryo-EM structure of the A.baumannii MlaBDEF complex bound to AppNHp
Not available
EMPIAR-10425 | biostudies-other
ProteomicsA Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with ad...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-11 | PXD004671 | Pride
T cell tolerance Foxp3 Cold exposure 
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096281 | MassIVE
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-16 | MSV000081089 | MassIVE
ProteomicsSystematic assessment of ISWI subunits reveals that NURF creates local accessibility for proper CTCF function
Catalytic activity of the ISWI family of remodelers is critical for nucleosomal organization and transcription factor binding, including the insulator protein CTCF. To define which subcomplex mediates these diverse functions we phenotyped a panel of isogenic mouse stem cell lines each lacking one of...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-13 | PXD042945 | Pride
Snf2h Chromatin remodelers Ip-ms Iswi Mesc 
UnknownAssessment of US Hospital Compliance With Regulations for Patients' Requests for Medical Records.
Not available
S-EPMC6324595 | biostudies-literature
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