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TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
UnknownAssociation of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study.
Not available
S-EPMC5617776 | biostudies-literature
UnknownRadiocarbon re-dating of contact-era Iroquoian history in northeastern North America.
Not available
S-EPMC6281431 | biostudies-literature
UnknownImproving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants.
Not available
S-EPMC12676392 | biostudies-literature
UnknownAmino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.
Not available
S-EPMC5901681 | biostudies-literature
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsSingle cell RNA sequencing of thymic dendritic cells reveals molecular determinants of antigen transfer in the thymus
The presentation of self-antigens in the thymus by medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) is crucial for the establishment of central tolerance. While mTECs produce and present self-antigens in an autonomous manner, DCs acquire them from mTECs by Cooperative Antigen Tran...
ORGANISM(S): Mus musculus 
2024-07-31 | E-MTAB-14319 | biostudies-arrayexpress
Genomicscis-eQTL mapping of human pancreatic islets
The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act remain po...
EGAS00001001265 | EGA
UnknownThe Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families.
Not available
S-EPMC1821046 | biostudies-literature
UnknownThe Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
Not available
S-EPMC1995613 | biostudies-literature
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