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ProteomicsLC-MS/MS analysis of Mannose 6-phosphate containing proteins
Mucolipidosis III gamma (MLIII) is clinically characterized by onset of first symptoms at an average of 5 years such as stiffness of hands and shoulders, claw hand deformities, scoliosis and progressive destruction of hip joints. The disease is caused by mutations in GNPTG encoding the gamma-subunit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-06 | PXD007546 | Pride
Secreted proteins : mouse embryonic fibroblasts Mannose 6-phosphate affinity purification 
ProteomicsComparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic DNMT1/3b double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway
N-glycoproteomic analyses provide valuable resources for investigation of cancer mechanisms, biomarkers, and therapeutic targets. Here, we mapped and compared the site-specific N-glycoproteomes of colon cancer HCT116 cells and isogenic non-tumorigenic DNMT1/3b double knockout (DKO1) cells using Fbs...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD035301 | Pride
Mannose-6-phosphate (m6p) Fbs1-gyr N-glycoproteome N-glycosylation Paucimannose 
UnknownThe mannose 6-phosphate glycoprotein proteome.
Not available
S-EPMC2739600 | biostudies-literature
UnknownCloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the mannose 6-phosphate isomerase from Salmonella typhimurium.
Not available
S-EPMC2374180 | biostudies-literature
ProteomicsLC-MS/MS analysis of Mannose 6-phosphate containing proteins
Mucolipidosis III gamma (MLIII) is clinically characterized by onset of first symptoms at an average of 5 years such as stiffness of hands and shoulders, claw hand deformities, scoliosis and progressive destruction of hip joints. The disease is caused by mutations in GNPTG encoding the gamma-subunit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-06 | PXD009621 | Pride
Mliii Gnptg M6p Lc-msms Affinitz chromatography 
ProteomicsTargeting of non-phosphorylated lysosomal enzymes involves secretion and Lrp1-mediated recapture
Most lysosomal enzymes require mannose 6-phosphate (M6P) residues for efficient receptor-mediated lysosomal targeting. Although the lack of M6P results in missorting and hypersecretion, selected lysosomal enzymes reach normal levels in lysosomes of various cell types suggesting the existence of M6P-...
ORGANISM(S): Mus musculus (Mouse) 
2015-05-01 | PXD001221 | Pride
Low density lipoprotein-related receptor/ lysosomal targeting/ mannose 6-phosphate/ receptor-mediated endocytosis/ sortilin 
UnknownBacterial expression of the phosphodiester-binding site of the cation-independent mannose 6-phosphate receptor for crystallographic and NMR studies.
Not available
S-EPMC4417374 | biostudies-literature
UnknownMannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.
Not available
S-EPMC3386966 | biostudies-literature
UnknownProteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
Not available
S-EPMC2909280 | biostudies-literature
UnknownDeciphering α-L-Fucosidase Activity Contribution in Human and Mouse: Tissue α-L-Fucosidase FUCA1 Meets Plasma α-L-Fucosidase FUCA2.
Not available
S-EPMC12427801 | biostudies-literature
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