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ProteomicsLC-MS/MS analysis of the cation-independent mannose 6-phosphate receptor (CI-MPR) from bovine serum
The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. Th...
ORGANISM(S): Bos taurus (Bovine) 
2024-05-20 | PXD052183 | Pride
Bovine Ci-mpr Lc-ms/ms 
ProteomicsComparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic DNMT1/3b double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway
N-glycoproteomic analyses provide valuable resources for investigation of cancer mechanisms, biomarkers, and therapeutic targets. Here, we mapped and compared the site-specific N-glycoproteomes of colon cancer HCT116 cells and isogenic non-tumorigenic DNMT1/3b double knockout (DKO1) cells using Fbs...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD035301 | Pride
Mannose-6-phosphate (m6p) Fbs1-gyr N-glycoproteome N-glycosylation Paucimannose 
ProteomicsLC-MS/MS analysis of Mannose 6-phosphate containing proteins
Mucolipidosis III gamma (MLIII) is clinically characterized by onset of first symptoms at an average of 5 years such as stiffness of hands and shoulders, claw hand deformities, scoliosis and progressive destruction of hip joints. The disease is caused by mutations in GNPTG encoding the gamma-subunit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-06 | PXD007546 | Pride
Secreted proteins : mouse embryonic fibroblasts Mannose 6-phosphate affinity purification 
ProteomicsTargeting of non-phosphorylated lysosomal enzymes involves secretion and Lrp1-mediated recapture
Most lysosomal enzymes require mannose 6-phosphate (M6P) residues for efficient receptor-mediated lysosomal targeting. Although the lack of M6P results in missorting and hypersecretion, selected lysosomal enzymes reach normal levels in lysosomes of various cell types suggesting the existence of M6P-...
ORGANISM(S): Mus musculus (Mouse) 
2015-05-01 | PXD001221 | Pride
Low density lipoprotein-related receptor/ lysosomal targeting/ mannose 6-phosphate/ receptor-mediated endocytosis/ sortilin 
UnknownIdentification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor.
Not available
S-EPMC4410830 | biostudies-literature
UnknownTissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate.
Not available
S-EPMC8050316 | biostudies-literature
UnknownMannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway.
Not available
S-EPMC3150748 | biostudies-literature
UnknownP-Type Lectins: Cation-Dependent Mannose-6-Phosphate Receptor
Not available
S-EPMC7121444 | biostudies-literature
UnknownStrategies for carbohydrate recognition by the mannose 6-phosphate receptors.
Not available
S-EPMC2733771 | biostudies-literature
UnknownStructure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor.
Not available
S-EPMC424385 | biostudies-literature
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