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TranscriptomicsThe genes regulated by SOX11 in mantle cell lymphoma
The genes regulated by SOX11 in MCL was investigated in MCL cell line Granta 519 by siRNA knock down system. Cells were transfected using the LONZA electroporation system. Results represent cells harvested after 20 hours. Details of the experiment is published in PMID 21124928. Gene expression profi...
ORGANISM(S): Homo sapiens 
2010-11-29 | E-GEOD-25621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human indolent mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the gen...
ORGANISM(S): Homo sapiens 
2010-03-04 | E-GEOD-16455 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
TranscriptomicsHigh resolution ChIP sequencing reveals novel bindings targets and prognostic role for SOX11 in Mantle cell lymphoma (RNA-Seq)
SOX11 (Sex determining region Y-box 11) expression is specific for MCL as compared to other Non-HodgkinM-bM-^@M-^Ys lymphomas. However, the function and direct binding targets of SOX11 in MCL are largely unknown. We used high-resolution ChIP-Seq to identify the direct target genes of SOX11 in a geno...
ORGANISM(S): Homo sapiens 
2014-08-07 | E-GEOD-52148 | biostudies-arrayexpress
TranscriptomicsSOX11 Gene Expression Profiling
The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL), but its functional role in malignant B-cells is unknown. To identify target genes transcriptionally regulated by SOX11 in malignant lymphoid cells, we have used Gene Expressi...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-34763 | biostudies-arrayexpress
UnknownBiomineral proteins from Mytilus edulis mantle tissue transcriptome.
Not available
S-EPMC3896809 | biostudies-literature
GenomicsTranscriptome profiling of Mantle Cell Lymphoma and healthy controls using RNA-seq
Transcriptome profiling of Mantle Cell Lymphoma and healthy controls using RNA-seq
PRJNA670484 | ENA
TranscriptomicsExpression data from MALD1 and MCL cases
Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-45717 | biostudies-arrayexpress
GenomicsPharmacological and genomic profiling identifies NFκB-targeted treatment strategies for mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive malignancy characterized by poor prognosis, underscoring the need for novel therapeutic strategies1. In this study, we employed large-scale pharmacological profiling of 16 pathway inhibitors across more than 100 hematological cell line models to identify n...
EGAS00001000622 | EGA
UnknownTranscriptome analysis of the bivalve Placuna placenta mantle reveals potential biomineralization-related genes.
Not available
S-EPMC8933548 | biostudies-literature
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