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Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
High-capacity methods for assessing gene function have become increasingly important because of the increasing number of newly identified genes emerging from large-scale genome sequencing and cDNA cloning efforts. We investigated the use of DNA microarrays to identify uncharacterized genes specifica...
ORGANISM(S): Homo sapiens 
Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...
ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590) 
2024-11-04 | MSV000096283 | MassIVE
While chimeric antigen receptor T-cell (CART) therapy has shown impressive therapeutic efficacy in several hematologic malignancies, primary or secondary treatment failure remains a significant challenge driving investigators to explore opportunities to improve the functionality of CART products. In...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD060508 | Pride
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
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