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ProteomicsSite-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry
The global pandemic of severe acute pneumonia syndrome (COVID-19) caused by SARS-CoV-2 urgently calls for prevention and intervention strategies. The densely glycosylated spike (S) protein highly exposed on the viral surface is a determinant for virus binding and invasion into host cells as well as ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD018506 | Pride
Sars-cov-2  spike protein  n-glycosylation  mass spectrometry 
ProteomicsComprehensive human plasma N-glycoproteome profiling based on EThcD-sceHCD-MS/MS
N-glycoproteins are involved in various biological processes. More than one-third of plasma tumor protein biomarkers approved by the Food and Drug Administration (FDA) are glycoproteins which would enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of pla...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030622 | Pride
Mass spectrometry  human plasma  n-glycoproteomics  combinatorial peptide ligands library  ethcd-scehcd 
ProteomicsOptimized Workflow for In-depth N-glycosylation Analysis of 2D and 3D Breast Cancer Cell Cultures and Xenografted Tumors
Native intact N-glycopeptides analysis can access to a lot of useful information including N-glycosites, N-glycans and N-glycoproteins of original complex samples. The traditional sample preprocessing method is to analyze the tryptic intact N-glycopeptides enriched using hydrophilic materials or som...
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD020254 | Pride
N-glycoproteomics Breast cancer Intact n-glycopeptides Zwitterionic hydrophilic interaction chromatography Mass spectrometry 
ProteomicsGlyco-CPLL: an integrated method for in-depth and comprehensive N-glycoproteome profiling of human plasma
N-glycoproteins are involved in various biological processes. Certain distinctive glycoforms on specific glycoproteins enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of plasma N-glycoproteome is essential for new biomarker discovery. Absence of suitab...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016428 | Pride
Mass spectrometry  papillary thyroid carcinoma  n-glycoproteomics  combinatorial peptide ligands library 
ProteomicsIntact N-glycopeptide signatures of immunoglobulin G molecules in plasma from patients with prostate carcinoma and benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) is difficult to discriminate from prostate carcinoma (PCa) preoperatively. The non-invasive biomarkers are necessary to reduce the burden of biopsies and improve survival quality of patients. Previous research suggests that abnormal glycosylation of immunoglobulin ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD016175 | Pride
Plasma Glycosylation Human Iggs 
ProteomicsSite-specific N-glycosylation Characterization of Micro Disease-related Proteins Based on EThcD-sceHCD-MS/MS
Monoclonal immunoglobulin produced by clonal plasma cells is the main cause in multiple myeloma and monoclonal gammopathy of renal significance. Because of the complicated purification method and the low stoichiometry of purified protein and glycans, site-specific N-glycosylation characterization fo...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD035757 | Pride
N-glycosylation  microscale  serum  monoclonal immunoglobulin  mass spectrometry  ethcd-scehcd 
ProteomicsComparative glycoproteomic profiling of human body fluid between healthy controls and patients with papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer among women worldwide. It is confirmed mainly by fine-needle aspiration biopsy (FNAB), an invasive diagnostic method. The key proteins responsible for thyroid hormone biosynthesis are glycosylated. Changes in site-specific g...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD015360 | Pride
Biomarker  mass spectrometry  site-specific n-glycopeptide  thyroid cancer 
ProteomicsEThcD-sceHCD-MS/MS-based Clinical N-glycoproteomics
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy collisional dissociation (sceHCD), and higher-ene...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030288 | Pride
Glycoproteomics Mass spectrometry Ethcd-scehcd Fragmentation mode N-glycosylation Clinical sample 
UnknownTwo new species of Oxycera (Diptera, Stratiomyidae) from Ningxia, China.
Not available
S-EPMC3368256 | biostudies-literature
UnknownDietary cadmium exposure assessment among the Chinese population.
Not available
S-EPMC5436861 | biostudies-literature
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