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MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
TranscriptomicsDepletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes
We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects. Primary human keratinocytes were electroporated with scra...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-15417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mkk1, mkk2 and mkk1/2 knockout treated with the saliicylic acid analog BTH
Gene Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase Kinases 2 (mkk2) knockout mutants and the double mutant mkk1/mkk2 before and 24 hours after treatment with the salicylic acid analog BTH, was measured by hybridisation to an Affymetrix ATH1 GeneChip. Experi...
ORGANISM(S): Arabidopsis thaliana 
2008-06-11 | E-GEOD-10646 | biostudies-arrayexpress
GenomicsTranscriptome profile of biopsies of melanoma patients responder or resistant to MAPKi (MAP-kinases inhibitors)
Transcriptome profile of biopsies of melanoma patients responder or resistant to MAPKi (MAP-kinases inhibitors)
PRJNA885477 | ENA
TranscriptomicsChromatin immunoprecipitation of activated yeast signal transduction protein kinases
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which they regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protei...
ORGANISM(S): Saccharomyces cerevisiae 
2006-07-28 | E-TABM-98 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of MAP Kinase-Mediated Meiotic Progression in C. elegans
A unique allele of MAP kinase, mpk-1(ga111), displays a reversible, temperature-sensitive, tissue-specific defect in progression through meiotic prophase I. We performed gene expression profiling on mpk-1(ga111) animals at multiple times after shift to permissive temperature to identify candidate d...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5069 | biostudies-arrayexpress
ProteomicsMAP2Ks can activate MAP kinases using ADP in vitro
Kinases are a diverse group of enzymes that use ATP to phosphorylate a variety of substrates. Protein kinases evolved in eukaryotes as important mediators of cell signalling that target specific amino acid side chains to modulate downstream protein function. Among them, the MAPKs (mitogen-activated ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-09-29 | PXD065314 | Pride
Kinase Adp Phosphorylation Mapk 
GenomicsDUX4 expression activates JNK and p38 MAP kinases in myoblasts
DUX4 expression activates JNK and p38 MAP kinases in myoblasts
PRJNA844998 | ENA
TranscriptomicsTranscriptome profile of biopsies of melanoma patients responder or resistant to MAPKi (MAP-kinases inhibitors)
To analyse gene expression differences between melanoma patients responder or resistant to MAPKi (MAP-kinases inhibitors).
ORGANISM(S): Homo sapiens 
2022-09-30 | GSE214473 | GEO
UnknownFunctions of p38 MAP Kinases in the Central Nervous System.
Not available
S-EPMC7509416 | biostudies-literature
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