Sort   by:  
 Page size 
TranscriptomicsExpression Profiling of MAP Kinase-Mediated Meiotic Progression in C. elegans
A unique allele of MAP kinase, mpk-1(ga111), displays a reversible, temperature-sensitive, tissue-specific defect in progression through meiotic prophase I. We performed gene expression profiling on mpk-1(ga111) animals at multiple times after shift to permissive temperature to identify candidate d...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5069 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis reveals Flg22 regulates MAP kinase 6 interaction with an ethylene response factor substrate via ethylene
Despite their importance, plant MAP kinase targets are still poorly elucidated. Here, the specific in vivo interaction of an ethylene response factor (ERF104) with the Arabidopsis MAP kinase, MPK6, is shown by fluorescence resonance energy transfer. The interaction, which is lost within minutes afte...
ORGANISM(S): Arabidopsis thaliana 
2009-05-27 | E-GEOD-11807 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adult mouse heart following activation of Ras, MKK3 and MKK7 mutant genes
Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have gener...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3530 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preimplantation mouse embryos to study the requirement of the MAP kinase signaling pathway for preimplantation development.
We examined expression profiles of genes that could be regulated by the MAPK pathways during mouse preimplantation development. We used Affymetrix GeneChips for microarray analysis, and three independent experiments were carried out. 8-cell stage embryos were treated or untreated with MAPK inhibit...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabdiopsis plants over-expressing MKK3DD or MKK4DD to identify genes acting downstream of MAP kinase kinase
To identify genes acting downstream of MAP kinase kinase, and thus map its signal, we used the steroid-inducible overexpression system. The constitutive active form MKK3 (MKK3DD) or MKK4 (MKK4DD) was cloned into the glucocorticoid-inducible vector pTA7002 and transformed using Agrobacterium method i...
ORGANISM(S): Arabidopsis thaliana 
2007-05-11 | E-MEXP-827 | biostudies-arrayexpress
TranscriptomicsCritical requirement of ERK/MAPK signaling in respiratory tract development
The mammalian genome contains two ERK/MAP kinase kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. To define the function of ERK/MAPK signaling pathway in lung development, we performed tissue-specific deletions of Mek1 function in a Mek...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-51643 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mkk1, mkk2 and mkk1/2 knockout treated with the saliicylic acid analog BTH
Gene Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase Kinases 2 (mkk2) knockout mutants and the double mutant mkk1/mkk2 before and 24 hours after treatment with the salicylic acid analog BTH, was measured by hybridisation to an Affymetrix ATH1 GeneChip. Experi...
ORGANISM(S): Arabidopsis thaliana 
2008-06-11 | E-GEOD-10646 | biostudies-arrayexpress
ProteomicsT. brucei MAPKLK1 knockdown - The MAP kinase MAPKLK1 is essential to Trypanosoma brucei proliferation and regulates proteins involved in mRNA metabolism
Pathogenic trypanosomatids have a large number of protein kinases and phosphatases in comparison to other organisms. Moreover, post-translational modifications have key role in the gene expression control in these cells, reinforcing the relevance of the phosphorylation process. Nevertheless little i...
ORGANISM(S): Trypanosoma brucei 
2017-10-17 | PXD006048 | Pride
Map kinase Ltq orbitrap xl etd Trypanosoma brucei 
GenomicsMAP Kinase inhibition depletes tumor-infiltrating macrophages in mouse pancreatic cancer [Verona]
MAP Kinase inhibition depletes tumor-infiltrating macrophages in mouse pancreatic cancer [Verona]
PRJNA576312 | ENA
GenomicsMAP Kinase inhibition depletes tumor-infiltrating macrophages in mouse pancreatic cancer [Essen]
MAP Kinase inhibition depletes tumor-infiltrating macrophages in mouse pancreatic cancer [Essen]
PRJNA576313 | ENA
Sort   by:  
 Page size