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TranscriptomicsCritical requirement of ERK/MAPK signaling in respiratory tract development
The mammalian genome contains two ERK/MAP kinase kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. To define the function of ERK/MAPK signaling pathway in lung development, we performed tissue-specific deletions of Mek1 function in a Mek...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-51643 | biostudies-arrayexpress
ProteomicsFunctional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
Human longevity, coupled to compression of age-related disease, is heritable. However, few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived families from th...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD063190 | Pride
Longevity Rare variants Functional characterisation Ageing Genetics Mapk/erk signalling pathway 
TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
TranscriptomicsL-plastin Ser5 phosphorylation via RSKs, downstream effectors of the MAPK/ERK pathway, in (breast) cancer cells (and in vitro)
Deregulated cell migration and invasion, which are hallmarks of metastatic cancer cells, are correlated to structural and functional alterations of the actin cytoskeleton associated to a large panel of actin-binding proteins. Among these, the actin-bundling protein L-plastin, initially detected in l...
ORGANISM(S): Homo sapiens 
2016-03-26 | E-MTAB-3487 | biostudies-arrayexpress
TranscriptomicsTranscriptional signature of wounded keratinocytes reveals selective roles for ERK1/2, P38 and PI3K signalling pathways
Covering denuded dermal surface after injury requires migration, proliferation and differentiation of skin keratinocytes. To clarify the major traits controlling these intermingled biological events, we surveyed the genomic modifications occurring during the course of a scratch closure of cultured h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-6820 | biostudies-arrayexpress
UnknownStrong negative feedback from Erk to Raf confers robustness to MAPK signalling.
Not available
S-EPMC3130559 | biostudies-literature
UnknownL-741626 inhibits hepatocellular carcinoma progression by targeting Ref-1 to suppress MAPK/ERK signalling pathway activity.
Not available
S-EPMC12001403 | biostudies-literature
ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [U266 human myeloma cell line]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66292 | biostudies-arrayexpress
UnknownLong non-coding RNA Malat1 promotes neurite outgrowth through activation of ERK/MAPK signalling pathway in N2a cells.
Not available
S-EPMC5082393 | biostudies-literature
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