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TranscriptomicsTranscription profiling of mouse livers from animals fed a ketogenic diet (KD), a diet high in fat and low in carbohydrates
Analysis of liver gene transcription during feeding of a ketogenic diet. Ketogenic diets may alter physiologic and metabolic profiles in a direction that favors weight loss. C57BL/6J mice were maintained for six weeks on either chow or ketogenic diet. Mice eating KD had lower weights, 90% reduction...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7699 | biostudies-arrayexpress
UnknownMethionine and choline regulate the metabolic phenotype of a ketogenic diet.
Low-carbohydrate ketogenic diets are commonly used as weight loss alternatives to low-fat diets, however the physiological and molecular adaptations to these diets are not completely understood. It is assumed that the metabolic phenotype of the ketogenic diet (KD) is caused by the absence of carbohy...
S-EPMC3773836 | biostudies-literature
UnknownReduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.
The concept that obesity is an inflammatory state has changed our understanding of this condition and suggested that pharmacological interventions targeting inflammation may be useful strategies to improve metabolic complications of obesity. Phosphodiesterase 4 (PDE4) inhibitors exhibit profound ant...
S-EPMC2703511 | biostudies-literature
UnknownFibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.
Fibroblast growth factor 21 (FGF21) is a key metabolic regulator. Expressed primarily in liver and adipose tissue, FGF21 is induced via peroxisome proliferator-activated receptor (PPAR) pathways during states requiring increased fatty acid oxidation including fasting and consumption of a ketogenic d...
S-EPMC2775979 | biostudies-literature
UnknownPolymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism.

Objective

Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization.

Research design and methods

PTRF expression was examined in d...
S-EPMC3046836 | biostudies-literature
UnknownVoluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice.
Exercise promotes weight loss and improves insulin sensitivity. However, the molecular mechanisms mediating its beneficial effects are not fully understood. Obesity correlates with increased production of inflammatory cytokines, which in turn, contributes to systemic insulin resistance. To test the ...
S-EPMC2536732 | biostudies-literature
UnknownElevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis.

Background

The metabolic regulator Fibroblast Growth Factor 21 (FGF21) is highly expressed in the acinar pancreas, but its role in pancreatic function is obscure. It appears to play a protective role in acute experimental pancreatitis in mice. The aim of this study was to define an associati...
S-EPMC5104316 | biostudies-literature
UnknownReduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of diabetic mice, leading to a reduction of cholesterol...
S-EPMC3621654 | biostudies-literature
UnknownFructose ingestion acutely stimulates circulating FGF21 levels in humans.

Objective

Fibroblast growth factor 21 (FGF21) is a hormone with pleiotropic metabolic activities which, in rodents, is robustly regulated by fasting and ketogenic diets. In contrast, similar dietary interventions have either no or minimal effects on circulating FGF21 in humans. Moreover, no ...
S-EPMC4314524 | biostudies-literature
UnknownThyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a dose-dependent increase i...
S-EPMC2863226 | biostudies-literature
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