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MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
GenomicsSingle-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
PRJNA593249 | ENA
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
UnknownUGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis.
Not available
S-EPMC10024420 | biostudies-literature
TranscriptomicsSingle-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
Macrophages are the most common infiltrating immune cells in glioblastoma (GBM), and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment remain poorly understood. Here, we combine new and previous...
ORGANISM(S): Homo sapiens 
2020-12-23 | GSE141383 | GEO
UnknownDraft genome of the Marco Polo Sheep (Ovis ammon polii).
Not available
S-EPMC5740985 | biostudies-literature
ProteomicsProteomic characterization of extracellular vesicles recovered from peripheral blood from a patient with active leishmaniasis in the context of HIV co-infection
Leishmania is an intracellular protozoan parasite and the etiological agent of a vector-borne disease known as leishmaniasis. This neglected tropical disease exhibits high morbidity and mortality. It is endemic in 97 countries and 700.000–1.000.000 new cases are estimated to occur each year. Leishma...
ORGANISM(S): Leishmania sp. 
2025-07-07 | PXD049001 | Pride
Leishmania  hiv-co infection  extracellular vesicles  biomarkers  marco 
UnknownProteomic Profiling Identifies MARCO in Extracellular Vesicles, as a Potential Biomarker for Leishmaniasis in HIV Co-Infection.
Not available
S-EPMC12193235 | biostudies-literature
UnknownA naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function.
Not available
S-EPMC4980223 | biostudies-literature
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