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TranscriptomicsTra1 has specific regulatory roles, rather than global functions, within the SAGA coactivator complex
The SAGA complex is a conserved, multifunctional coactivator that plays broad roles in eukaryotic transcription. Previous studies suggested that Tra1, the largest SAGA component, is required either for SAGA assembly or for recruitment by DNA-bound transcriptional activators. In contrast to S. cere...
ORGANISM(S): Schizosaccharomyces pombe 
2011-06-13 | E-MTAB-678 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast SAGA mutants shows that the SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8
The SAGA complex is a conserved multifunctional coactivator known to play broad roles in eukaryotic transcription. To gain new insights into its functions, we have performed biochemical and genetic analyses of SAGA in the fission yeast, Schizosaccharomyces pombe. Purification of the S. pombe SAGA ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-11-19 | E-MTAB-53 | biostudies-arrayexpress
TranscriptomicsContributions of transcription and mRNA turnover to gene expression dynamics of fission yeast in response to oxidative stress
The cooperation of transcriptional and post-transcriptional controls to shape gene regulation is poorly understood. Here we show that a combination of two simple and non-invasive genomic techniques, coupled with kinetic mathematical modelling, afford insight into the multi-layered regulation of gene...
ORGANISM(S): Schizosaccharomyces pombe 
2014-06-01 | E-MTAB-2579 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of poly(A) site selection in Schizosaccharomyces pombe
Polyadenylation of pre-mRNAs, a critical step in eukaryotic gene expression, is mediated by cis elements, collectively called the polyadenylation signal. Genome-wide analysis of such polyadenylation signals was missing in fission yeast, which is an important model organism. We demonstrate that the c...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-01 | E-MTAB-1824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Schizosaccharomyces pombe transcriptome during both proliferation and quiescence
Data on absolute molecule numbers are rare but will empower the modeling, understanding and comparison of cellular functions and biological systems. We quantified transcriptomes and proteomes in fission yeast during both proliferation and quiescence. This rich resource provides the first comprehensi...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-28 | E-MTAB-1153 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of Schizosaccharomyces pombe transcriptome during both proliferation and quiescence
Data on absolute molecule numbers are rare but will empower the modeling, understanding and comparison of cellular functions and biological systems. We quantified transcriptomes and proteomes in fission yeast during both proliferation and quiescence. This rich resource provides the first comprehensi...
ORGANISM(S): Schizosaccharomyces pombe 
2012-10-26 | E-MTAB-1154 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast strains identifies widespread requirement for SWI/SNF and RSC on transcription
SWI/SNF chromatin remodeling complexes play critical roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-06-13 | E-MTAB-31 | biostudies-arrayexpress
GenomicsThe RNA Exosome Promotes Transcription Termination of backtracked RNA Polymerase II
Large fractions of genomes are expressed in most eukaryotic cells, generating a diverse repertoire of protein-coding and non-coding transcripts. With such complexity, and as the number of mRNA molecules per cell are often low, it is clear that errors anywhere in the gene expression process could hav...
ORGANISM(S): Schizosaccharomyces pombe 
2014-09-20 | E-MTAB-2237 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of yeast FBY107, FBY106 strains to investigate pre-mRNA degradation pathway
General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a nuclear pre-mRNA degradation pathway that controls the expression of select intron-containing genes. We show that the fissi...
ORGANISM(S): Schizosaccharomyces pombe 
2012-02-10 | E-MTAB-708 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast under multiple conditions, including exponential proliferation, meiotic differentiation and environmental stress, and in RNA processing mutants
Recent data from several organisms indicate that the transcribed portions of genomes are larger and more complex than expected, and many functional properties of transcripts are not based on coding sequences but on regulatory sequences in untranslated regions or non-coding RNAs. Alternative start a...
ORGANISM(S): Schizosaccharomyces pombe 
2008-05-18 | E-MTAB-18 | biostudies-arrayexpress
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