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TranscriptomicsEvaluation of differential expression in the vascular transcriptome among Picea species
The goal of this experiment is to assess tissue preferential transcript accumulation and fold difference between two tissues that support secondary vascular growth in three spruces: Picea glauca, Picea sitchensis and Picea mariana. Tissues compared are secondary xylem (wood forming tissue located on...
ORGANISM(S): Picea sitchensis 
2012-02-18 | E-GEOD-35922 | biostudies-arrayexpress
TranscriptomicsIL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals.
HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we investigated the global gene expression profile of circulating CD4+ T cells from distinct clinical status of HTLV-1-infected individuals in regard to Tax expression levels. CD4+ T ce...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-38537 | biostudies-arrayexpress
TranscriptomicsDistinctive genotypes in infants with T-cell acute lymphoblastic leukaemia
Infant T-cell Acute Lymphoblastic Leukaemia (iT-ALL) is a very rare and poorly defined entity with a poor prognosis. We assembled a unique series of thirteen cases of infants with T-ALL which allowed us to identify genotypic abnormalities and to investigate prenatal origins. Matched samples (diagn...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-67271 | biostudies-arrayexpress
TranscriptomicsExpression data from Toxoplasma gondii mutants and wild-type during bradyzoite differentiation in vitro
Toxoplasma gondii pathogenesis includes the invasion of host cells by extracellular parasites (tachyzoites), replication of intracellular tachyzoites, and differentiation to a latent bradyzoite stage. Whole genome expression profiling was carried out using the newly developed Affymetrix ToxoGeneChip...
ORGANISM(S): Toxoplasma gondii 
2010-07-27 | E-GEOD-23174 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis thaliana
Nitrogen and light are two major regulators of plant metabolism and development. While genes involved in the control of each of these signals have begun to be identified, regulators that integrate gene responses to nitrogen and light signals have yet to be determined. Here, we evaluate the role of ...
ORGANISM(S): Arabidopsis thaliana 
2010-08-25 | E-GEOD-21601 | biostudies-arrayexpress
TranscriptomicsExpression data from Oryza sativa and Arabidopsis thaliana
The goal of this work is to identify the gene regulatory hubs that control nitrogen-use in Oryza sativa, one of the most important crop plants, by using a combination of genomics, bioinformatics and systems biology approaches. Here, we evaluate the role of bZIP1, a transcription factor involved in l...
ORGANISM(S): Arabidopsis thaliana 
2015-06-10 | E-GEOD-38102 | biostudies-arrayexpress
TranscriptomicsThe peroxisome proliferator-activated receptor-gamma agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus
Previous studies indicate that peroxisome proliferator-activated receptor-gamma (PPAR-g) agonists suppress autoimmune responses and renal inflammation in murine lupus. However, the mechanisms implicated in this process remain unclear. We tested the effect of the PPAR-g agonist pioglitazone in human ...
ORGANISM(S): Homo sapiens 
2014-12-08 | E-GEOD-45923 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context- dependent fitness genes, we have developed a high-complexity second-generation ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75189 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on schistosomulum stage of Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16260 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on adult Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16261 | biostudies-arrayexpress
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