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MetabolomicsMetabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses
Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...
2021-08-31 | MTBLS2579 | MetaboLights
TranscriptomicsCD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients
We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of ...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-MTAB-3266 | biostudies-arrayexpress
UnknownImproved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8+ T-cell epitopes.
Not available
S-EPMC9811684 | biostudies-literature
UnknownExploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy.
Not available
S-EPMC11569243 | biostudies-literature
ProteomicsEstrogen receptor beta isoforms interplay integrates nuclear and extra-nuclear signaling to modulate human granulosa cell growth
Estradiol (E2) is a central regulator of ovarian follicle development and granulosa cells (GCs) function, acting predominantly through estrogen receptor β (ERβ) in GCs. Human GCs co-express multiple ERβ isoforms (ERβ1, ERβ2, ERβ4 and ERβ5), yet how their relative abundance and crosstalk determine es...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD073667 | Pride
Signaling crosstalk Nuclear signaling Extra-nuclear signaling Estrogen receptor beta isoforms Cell growth Protein interactions Human granulosa cells Estradiol 
UnknownResults from a clofarabine-busulfan-containing, reduced-toxicity conditioning regimen prior to allogeneic stem cell transplantation: the phase 2 prospective CLORIC trial.
Not available
S-EPMC4562538 | biostudies-literature
UnknownTumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.
Not available
S-EPMC8029323 | biostudies-literature
TranscriptomicsGenomic alterations in primary hyperaldosteronism
Transcriptome comparison of an aldosterone producing adenoma transcriptome and its adjacent zona glomerulosa. Both tissues are from the same individual, are differentiated for aldosterone production, but the adjacent zona glomerulosa produces no aldosterone by negative feedback. Keywords = aldostero...
ORGANISM(S): Homo sapiens 
2005-10-11 | E-GEOD-2017 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
TranscriptomicsRNA-seq of human primary ovarian granulosa cells with knockdown of ESR2 isoform 1, treated with estradiol
ERβ1 is the predominant isoform mediating transcriptional activity in granulosa cells; however, ERβ1-specific target genes remain largely unknown. Here, we performed transcriptomic analysis of primary human granulosa cells with specific knockdown of ERβ1 and stimulation with estradiol (E2), an ERβ a...
ORGANISM(S): Homo sapiens 
2026-06-30 | E-MTAB-16651 | biostudies-arrayexpress
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