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TranscriptomicsPermissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. This therapy relies on efficient replication of virus in tumor cells in vivo with minimal or no replication in normal tissues. We recently described GLV-1h68 as a modified Vaccinia Virus (VACV) constr...
ORGANISM(S): Homo sapiens 
2012-03-24 | E-GEOD-28472 | biostudies-arrayexpress
TranscriptomicsGene expression profiling on FePro labeled bone marrow stromal cells
Superparamagnetic iron oxide nanoparticles (SPION) are increasingly used to label human bone marrow stromal cells (BMSCs, also called mesenchymal stem cells) to monitor their fate by in vivo MRI and histology after Prussian blue (PB) staining. SPION-labeling appears to be safe as assessed by in vitr...
ORGANISM(S): Homo sapiens 
2011-01-24 | E-GEOD-20431 | biostudies-arrayexpress
TranscriptomicsType-1-cytokines synergize with oncogene inhibition to induce tumor growth arrest
Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer but responses are either short-lived or incompletely effective. Oncogene inhibition can augment the efficacy of immune-based therapy but mechanisms by which...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62249 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of Human Bone Marrow Stromal Cells (BMSCs)
Abstract Background: Bone marrow stromal cells (BMSCs) are being used for immune modulatory, anti-inflammatory and tissue engineering applications, but the properties responsible for these effects are not completely understood. Human BMSCs were characterized to identify factors that might be respons...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24871 | biostudies-arrayexpress
TranscriptomicsInterferon-gamma critically determines dendritic cell function
A growing body of evidence suggests that inflammatory cytokines have a dualistic role in immunity. In this study, we sought to determine the direct effects IFN-gamma on the differentiation and maturation of human peripheral blood monocyte-derived dendritic cells (moDC). Here, we report that followin...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-47621 | biostudies-arrayexpress
TranscriptomicsMDSC exacerbate acute hepatitis, mature and loose suppressor function CD40 dependent
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous population of immature myeloid cells that accumulate in blood, liver, spleen and tumors upon chronic inflammation and tumor development in patients and mice. Acute hepatitis is characterized by a fast infiltration of inflammatory cell...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-50949 | biostudies-arrayexpress
TranscriptomicsExpression data analyzing ID3 (Inhibitor of DNA binding 3)-affected mouse T cells
Mouse CD8+ T cells affected by ID3 (Inhibitor of DNA binding 3) display patterns of gene expression suggesting enhanced persistance and survival. In this study, we identified genes differentially expressed between ID32a transduced and mock transduced, and ID32a knockout and wild type mouse CD8+ T ce...
ORGANISM(S): Mus musculus 
2011-10-15 | E-GEOD-23568 | biostudies-arrayexpress
TranscriptomicsExpression data from human naïve (TN), stem cell memory (TSCM), central memory (TCM) and effector memory (TEM) CD8+ T cells
An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the naïve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-sp...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-23321 | biostudies-arrayexpress
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