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ProteomicsIncreased EThcD efficiency on the hybrid Orbitrap Excedion Pro Mass Analyzer extends the depth in identification and sequence coverage of HLA class I immunopeptidomes
Gaining a complete and unbiased understanding of the non-tryptic peptide repertoire presented by HLA-I complexes by LC-MS/MS is indispensable for therapy design for cancer, autoimmunity and infectious diseases. A serious concern in HLA peptide analysis is that the routinely used, collision-based fra...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD064573 | Pride
Mass spectrometry Immunopeptidomics Ethcd 
ProteomicsExtending proteome coverage through an on-line 2D SCX-RP ultra-high pressure system
Ultra high pressure liquid chromatography (UHPLC) systems combined with state of the art mass spectrometers have pushed the limit of deep proteome sequencing to new heights making it possible to identify thousands of proteins in a single LC/MS experiment within a few hours. However, the relationship...
ORGANISM(S): Homo sapiens (Human) 
2014-09-30 | PXD000705 | Pride
2d lc-ms/ms Proteomics 
ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
UnknownWorking memory and decision making in children with ADHD: an analysis of delay discounting with the use of the dual-task paradigm.
Not available
S-EPMC7268601 | biostudies-literature
OtherRapid Analyses of Proteomes and Interactomes Using an Integrated Solid-Phase Extraction-Liquid Chromatography-MS/MS System.
Data from ProteomeXchange, PXD ID: PXD001111. Experiment: NYLON_Hela, file: OR7_20130627_NB_Nylon_Hela_1ug_top20_1.mzml. Published as part of J Proteome Res. 2014 Dec 8 . From the Abstract: {{i}} Here, we explore applications of a LC system using disposable solid-phase extraction (SPE) cartridges a...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310005326 | GPMDB
Resource Reanalysis 
ProteomicsHigh-throughput MS-based immunopeptidomics
Comprehensive knowledge of the HLA class-I and class-II peptides presented to T-cells is crucial for designing innovative therapeutics against cancer and other diseases. However methodologies for their extraction for mass-spectrometry analysis have been a major limitation. We designed a novel high-t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-19 | MSV000082184 | MassIVE
ProteomicsExtending proteome coverage through an on-line 2D SCX-RP ultra-high pressure system
Ultra high pressure liquid chromatography (UHPLC) systems combined with state of the art mass spectrometers have pushed the limit of deep proteome sequencing to new heights making it possible to identify thousands of proteins in a single LC/MS experiment within a few hours. However, the relationship...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080845 | MassIVE
UnknownSocial Cognition Impairments in 22q11.2DS Individuals With and Without Psychosis: A Comparison Study With a Large Population of Patients With Schizophrenia.
Not available
S-EPMC11205897 | biostudies-literature
ProteomicsSampling from proteome to HLA-DR ligandome
Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-24 | MSV000082848 | MassIVE
UnknownAnalysis of survival rate and persistence predictors of baricitinib in real-world data from a large cohort of rheumatoid arthritis patients.
Not available
S-EPMC10899020 | biostudies-literature
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