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GenomicsGene expression differences among primates are associated with changes in a histone epigenetic modification
Changes in gene regulation are thought to play an important role in speciation and adaptation, especially in primates. However, we still know relatively little about the mechanisms underlying regulatory evolution. In particular, the extent to which epigenetic modifications underlie gene expression d...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-24111 | biostudies-arrayexpress
TranscriptomicsSex-specific and lineage-specific alternative splicing in primates
Comparative studies of gene regulation suggest an important role for natural selection in shaping gene expression patterns within and between species. Most of these studies, however, estimated gene expression levels using microarray probes designed to hybridize to only a small proportion of each gen...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17274 | biostudies-arrayexpress
TranscriptomicsEffect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data.
Next-generation sequencing has become an important tool for genome-wide quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short sequence reads back to their correct locations in a reference genome. Here we investigate the impact of SNP variation on the reliab...
ORGANISM(S): Homo sapiens 
2009-10-22 | E-GEOD-18156 | biostudies-arrayexpress
GenomicsGenome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation
Fertilization triggers a global erasure of 5-methylcytosine from paternal DNA as part of extensive epigenetic reprogramming during the transition from gametic specialization to totipotency. This active removal has been shown to involve oxidation by TET3, but the targeting of this pathway and the wid...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-63417 | biostudies-arrayexpress
UnknownContributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.
Not available
S-EPMC4286248 | biostudies-literature
UnknownA spatial human thymus cell atlas mapped to a continuous tissue axis.
Not available
S-EPMC11578893 | biostudies-literature
UnknownA human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates.
Not available
S-EPMC7618435 | biostudies-literature
UnknownCells of the human intestinal tract mapped across space and time.
Not available
S-EPMC8426186 | biostudies-literature
UnknownA human embryonic limb cell atlas resolved in space and time.
Not available
S-EPMC7616500 | biostudies-literature
UnknownA spatial human thymus cell atlas mapped to a continuous tissue axis.
Not available
S-EPMC10659407 | biostudies-literature
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