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Gene expression in human optic nerve head (ONH) astrocytes exposed to either 60 mm Hg hydrostatic pressure (HP) or control ambient pressure (CP) was compared using Affymetrix GeneChip microarrays to identify HP-responsive genes. Primary ONH astrocytes from two male Caucasian donors (passage 4) were ...
ORGANISM(S): Homo sapiens 
Zebrafish (n=420; 70/treatment) were weighed and placed in 8L aerated tanks,
served with flow-through soft-water at 25ml/min. A combination of Mariotte bottles
were used to dose tanks with Cu (concentrated Cu solution made from CuSO4 dissolved
in 0.05% HNO3), Na (concentrated NaCl solution)...
ORGANISM(S): Danio rerio 
Mitochondrial mRNAs encode key subunits of the oxidative phosphorylation complexes that produce energy for the cell. In Saccharomyces cerevisiae, mitochondrial translation is under the control of translational activators, specific to each mRNA. In Schizosaccharomyces pombe, which more closely resemb...
ORGANISM(S): Schizosaccharomyces pombe 927 
2021-10-11 | PXD025400 | Pride
The aim of this experiment is to assess the genome-wide occupancy of Bye1, TFIIS and RNA polymerase II in yeast Saccharomyces cerevisiae by ChIP-chip
ORGANISM(S): Saccharomyces cerevisiae 
Astrocytes from optic nerve head from donors with and without glaucoma
ORGANISM(S): Homo sapiens 
In this study that was specifically designed to identify early stages of glaucoma in DBA/2J mice, we used genome-wide expression profiling and a series of computational methods. Our methods successfully subdivided eyes with no detectable glaucoma by conventional assays into molecularly defined stage...
ORGANISM(S): Mus musculus 
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