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ProteomicsTight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
Authors: David R. Amici, Sammy Alhayek, Austin T. Klein, Yi-Zhi Wang, Anika P. Wilen, Weimin Song, Pei Zhu, Abhishek Thakkar, McKenzi A. King, Adam Steffeck, Milad J. Alasady, Clara Peek, Jeffrey N. Savas, Marc L. Mendillo* ABSTRACT The recently discovered HAPSTR1 protein broadly oversees cellular ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-26 | MSV000094168 | MassIVE
GenomicsIn vivo live imaging of RNA polymerase II transcription factories in primary cells
Transcription steps are marked by different modifications of the C-terminal domain of RNA polymerase II (RNAPII). Phosphorylation of Ser5 and Ser7 by cyclin-dependent kinase 7 (CDK7) as part of TFIIH marks initiation, whereas phosphorylation of Ser2 by CDK9 marks elongation. These processes are thou...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-46849 | biostudies-arrayexpress
TranscriptomicsGene regulation in denervated hairy skin of the adult rat
This study aimed to quantify the regulation of transcripts in the hairy skin of the back of adult rats in the condition of loss of sensory and autonomic (sympathetic) innervation (i.e., denervated). Denervated skin has reduced wound healing capacity, reduced proliferation of epidermal progenitor cel...
ORGANISM(S): Rattus norvegicus 
2014-04-08 | E-GEOD-54356 | biostudies-arrayexpress
TranscriptomicsBroad shifts in gene expression during early postnatal life are associated with shifts in histone methylation patterns
During early postnatal life, extensive changes in gene expression occur concomitantly in multiple major organs, indicating the existence of a common core developmental genetic program. This program includes hundreds of growth-promoting genes that are downregulated with age in liver, kidney, lung, an...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-49785 | biostudies-arrayexpress
UnknownMicrobial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.
Not available
S-EPMC3150728 | biostudies-literature
UnknownOncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity.
Not available
S-EPMC11725805 | biostudies-literature
UnknownMulti-omics profiling of mouse gastrulation at single-cell resolution.
Not available
S-EPMC6924995 | biostudies-literature
UnknownBET inhibitor resistance emerges from leukaemia stem cells.
Not available
S-EPMC6069604 | biostudies-literature
GenomicsChIP of BET proteins in iBET resistance [ChIP-seq]
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63682 | biostudies-arrayexpress
TranscriptomicsGenome wide expression analysis of BET inhibitor resistance [RNA-seq]
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63681 | biostudies-arrayexpress
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