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TranscriptomicsGATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we analyzed the effect of on gene expression upon ectopic expression of Gata1s or Gata1, while simultaneously knocking down endogenous GATA1,...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56332 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Down Syndrome (DS)-AMKL and non-DS AMKL samples
The goal of this study is to define a gene expression signature unique to DS-AMKL (acute megakaryoblastic leukemia or FAB M7 leukemia). A similar study was done previously, but using unfractionated patient leukemic samples. In this study, we sorted megakaryocytic leukemia blasts from patients and th...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-16677 | biostudies-arrayexpress
TranscriptomicsRescue of murine Gata1s mutant M7 leukemic cells by full-length Gata1
In this project, we studied a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the GATA1 transcription factor (called GATA1s mutation). The model was generated through retroviral insertional mutagenesis in Gata1s mutant fetal liver progenitors. In this study, we...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16676 | biostudies-arrayexpress
TranscriptomicsDevelopmental stage-specific interplay between GATA1 and IGF signaling in fetal hematopoiesis and leukemogenesis
This SuperSeries is composed of the following subset Series: GSE16676: Rescue of murine Gata1s mutant M7 leukemic cells by full-length Gata1 GSE16677: Gene expression profiling of Down Syndrome (DS)-AMKL and non-DS AMKL samples GSE16679: Plag1 overexpression cooperates with Evi1 overexpression and G...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16655 | biostudies-arrayexpress
TranscriptomicsMurine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors
The goal of this study is to derive a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the hematopoietic transcription factor, GATA1 (called GATA1s mutation). We achieved this through transduction of Gata1s mutant fetal progenitors by MSCV-based retrovirus expre...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16682 | biostudies-arrayexpress
TranscriptomicsMurine M7 leukemia derived from retroviral insertional mutagenesis of Gata1s fetal progenitors depends on IGF signaling
The goal of this study is to derive a mouse model of human Down Syndrome (DS) megakaryocytic leukemia involving mutations in the hematopoietic transcription factor, GATA1 (called GATA1s mutation). We achieved this through transduction of Gata1s mutant fetal progenitors by MSCV-based retrovirus expre...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16684 | biostudies-arrayexpress
TranscriptomicsPlag1 overexpression cooperates with Evi1 overexpression and Gata1s mutation in leading to M7 leukemia
The goal of this study is to develop a Plag1 signature and determine how its overexpression contributes to leukemogenesis. To study this, we transduced an immortalized (but not transformed) cell line (derived from Gata1s mutant fetal liver progenitor through insertional mutagenesis) by Plag1-expres...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-16679 | biostudies-arrayexpress
UnknownRecognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase.
Not available
S-EPMC10598209 | biostudies-literature
UnknownThe non-coding RNA landscape of human hematopoiesis and leukemia.
Not available
S-EPMC5550424 | biostudies-literature
UnknownGATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.
Not available
S-EPMC4047213 | biostudies-literature
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