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ProteomicsHistone post-translational modification analysis from low-abundance clinical samples
We streamlined the protein extraction procedure from low-amount clinical samples and tested and implemented different in-gel digestion strategies, obtaining a protocol that allows the analysis of the most common histone PTMs from laser microdissected tissue areas containing as low as 1000 cells. We ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-09 | PXD024799 | Pride
Laser microdissection Breast cancer Histone post-translational modification 
ProteomicsComparison of in-gel digestion methods for histone PTM analysis
In order to optimize the histone digestion procedure for low-abundance clinical samples, we compared different in-gel digestion protocols. Histones are usually digested in-gel using “Arg-C-like” strategies, which involve chemical acylation of lysines followed by trypsin digestion (17). Acylated lysi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD024745 | Pride
Epigenetics Histone post-translationa modification 
UnknownAccuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem).
Not available
S-EPMC9213280 | biostudies-literature
GenomicsItalian Primary Biliary Cirrhosis Study

A Genome-wide association study of primary biliary cirrhosis (PBC) with an Italian cohort and loci meeting suggestive criteria were confirmed using a replication dataset from a previous Canadian study. The results confirmed associations for IL12A, IL12RB2, and HLA (peak between DQA1 and DQB1) and...

phs000444.v1.p1 | EGA
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