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TranscriptomicsProtective unfolded protein response in human pancreatic beta cells transplanted into mice
Islet transplantation exposes beta cells to mild hyperglycemia and to the abnormal environment of the transplant site. These conditions may affect beta cells and induce the expression of genes involved in beta cell damage. Gene expression profile of human beta cells exposed to mild hyperglycemia by ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22097 | biostudies-arrayexpress
TranscriptomicsThe human pancreatic islet transcriptome: impact of pro-inflammatory cytokines
We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress
TranscriptomicsNova1 is a master regulator of alternative splicing in pancreatic beta cells
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the M-bM-^@M-^\neuron spe...
ORGANISM(S): Rattus norvegicus 
2014-10-01 | E-GEOD-59633 | biostudies-arrayexpress
UnknownPer-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.
Not available
S-EPMC3052475 | biostudies-literature
UnknownADCY5 couples glucose to insulin secretion in human islets.
Not available
S-EPMC4141364 | biostudies-literature
ProteomicsTime course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Time course treatment with 0.4 mM Palmitate and 200 nM thapsigargin of insulinoma INS-1E cells. Timepoints; 0, 4, 16 and 24h in biological duplicates within an iTRAQ 8 set for palmitate and thapsigargin, respectively.
ORGANISM(S): Rattus Rattus (black Rat) 
2020-08-18 | PXD020851 | JPOST Repository
UnknownMetabolic response of Insulinoma 1E cells to glucose stimulation studied by fluorescence lifetime imaging.
Not available
S-EPMC7354695 | biostudies-literature
TranscriptomicsExpression data from pancreatic beta-cells obtained from type 2 diabetic subjects and non-diabetic controls
Changes in gene expression in pancreatic β cells from type 2 diabetes should provide insights into their abnormal insulin secretion and turnover. Gene expression profile of β cells obtained from type 2 diabetic subjects and non-diabetic controls was evaluated by microarray analysis. Frozen section...
ORGANISM(S): Homo sapiens 
2010-03-20 | E-GEOD-20966 | biostudies-arrayexpress
UnknownEndogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.
Not available
S-EPMC8005246 | biostudies-literature
UnknownPTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.
Not available
S-EPMC3219938 | biostudies-literature
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