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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
ProteomicsPhenotypic manifestation of-synuclein strains amplified from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
Although-synuclein is implicated in the pathogenesis of Parkinson’s disease and related disorders, it remains unclear whether specific conformations or levels of-synuclein assemblies are toxic and how they cause progressive loss of human dopaminergic neurons. To address this issue, we used iPSC-deri...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD024198 | Pride
Silac -synuclein Bioid Parkinson’s disease 
UnknownPhenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.
Not available
S-EPMC8217249 | biostudies-literature
TranscriptomicsTranscription profiling of human macrophages from Crohns disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli;
Comparison of gene expression in macrophages from Crohn's disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli
ORGANISM(S): Homo sapiens 
2009-08-03 | E-TABM-733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human macrophages from ulcerative colitis patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli
Comparison of gene expression in macrophages from ulcerative colitis patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli
ORGANISM(S): Homo sapiens 
2009-08-03 | E-TABM-734 | biostudies-arrayexpress
UnknownElevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer.
Not available
S-EPMC3542279 | biostudies-literature
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
UnknownA LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Not available
S-EPMC4869849 | biostudies-literature
TranscriptomicsTranscription profiling of mouse blood from native and Plasmodium berghei induced experimental cerebral malaria untreated or treated with activated charcoal.
We found that oral activated charcoal (oAC) provided significant protection against P. berghei ANKA-induced ECM, significantly increasing overall survival time compared to untreated mice. Protection from ECM by oAC was associated with a reduced numbers of splenic TNF+ CD4+ T cells and multifunction...
ORGANISM(S): Mus musculus 
2010-04-01 | E-MEXP-2594 | biostudies-arrayexpress
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
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