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MetabolomicsGut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
UnknownTherapeutic targeting of integrin αvβ6 in breast cancer.

Background

Integrin αvβ6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of αvβ6 has yet to be elucidated in breast cancer.

Methods

Protein expression of integrin subunit beta6 (β6) was measured in breast cancers by immunohistochemistry (n >...
S-EPMC4151855 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.

Background

Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

Methods

In this controlled, open-label trial comparing a range of poss...
S-EPMC7383595 | biostudies-literature
UnknownPrediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study.

Background

Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking ...
S-EPMC4373455 | biostudies-literature
UnknownGlobal outbreak research: harmony not hegemony.
Not available
S-EPMC7266570 | biostudies-literature
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

Background

Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial ...
S-EPMC3145073 | biostudies-literature
UnknownConvergence of genes and cellular pathways dysregulated in autism spectrum disorders.
Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus control groups (1.41-fold, p = 1.0 × 10(-5)) and an increase in affected subjec...
S-EPMC4067558 | biostudies-literature
UnknownResearching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.

Importance

SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-d...
S-EPMC10289397 | biostudies-literature
UnknownClinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Objective

To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels...
S-EPMC4843946 | biostudies-literature
UnknownCircular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Background

Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sli...
S-EPMC10579282 | biostudies-literature
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