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TranscriptomicsrG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
RNA structures are of crucial importance for biological function and gene regulation. Guanine (G)-rich sequences in RNA can assemble to form RNA G-quadruplex (rG4) structures; specific rG4s have been shown to regulate gene expression, and are associated with human diseases. However, no transcriptome...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-77282 | biostudies-arrayexpress
TranscriptomicsG-quadruplex structures mark human regulatory chromatin
DNA secondary structures are important for fundamental genome functions such as transcription and replication1. The G-quadruplex (G4) structural motif has been linked to gene regulation2,3 and genome instability4,5 and may be important to cancer development and other diseases6-8. Recently, ~700,000 ...
ORGANISM(S): Homo sapiens 
2016-08-05 | E-GEOD-76688 | biostudies-arrayexpress
UnknownPistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway.
Not available
S-EPMC7652607 | biostudies-literature
TranscriptomicsDSBCapture: in situ capture and direct sequencing of dsDNA breaks
Double-strand DNA breaks (DSBs) continuously arise and are a source of mutations and chromosomal rearrangements. Here, we present DSBCapture, a sequencing-based method that captures DSBs in situ and directly maps these at single nucleotide resolution enabling the study of DSB origin. DSBCapture show...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78172 | biostudies-arrayexpress
UnknownTRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable RAS and BRAF wild-type metastatic colorectal cancer.
Not available
S-EPMC6045747 | biostudies-literature
UnknownContemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM-HF registry.
Not available
S-EPMC12803666 | biostudies-literature
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