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TranscriptomicsExpression data in splenic DC subsets in wild type and Xbp1 deficient mice
Xbp1 is a major transcription factor in the unfolded protein response. To uncover its function in DCs we generated a conditional KO for Xbp1 in dendritic cells. We here compare the expression of mRNAs in two different splenic DC subpopulations, CD8a and CD11b DCs in both WT and KO mice. Reference: I...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52857 | biostudies-arrayexpress
TranscriptomicsCapacity of yolk sac macrophages, fetal liver and adult monocytes to colonize an empty niche and develop into functional tissue resident macrophages
Tissue-resident macrophages can derive from yolk sac macrophages, fetal liver monocytes or adult bone marrow monocytes. Whether these precursors can give rise to transcriptionally identical alveolar macrophages is unknown. Here, we transferred traceable yolk sac macrophages, fetal liver monocytes, a...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-76999 | biostudies-arrayexpress
TranscriptomicsBone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-reside...
ORGANISM(S): Mus musculus 
2015-11-21 | E-GEOD-75225 | biostudies-arrayexpress
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