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TranscriptomicsDissecting the specific role of Oct4 during the early stage of reprogramming
Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) following the forced overexpression of a specific combination of transcription factors, of which Oct4 is essential. To better understand the mechanism underlying iPSC reprogramming, we investigated the immediate tr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47061 | biostudies-arrayexpress
TranscriptomicsReprogramming to pluripotency through a somatic stem cell intermediate
In the past years, transdifferentiation from one lineage to another has become an important research field. In that context, we recently reported the direct reprogramming of mouse embryonic fibroblasts (MEFs) into induced neural stem cells (iNSCs). In this study, we, for the first time, successfully...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-44284 | biostudies-arrayexpress
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