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TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
ProteomicsCMK LC-MS/MS after CoIP of ARID3A
In order to determine proteins interacting with ARID3A in the ML-DS cell line CMK, we performed CoIP of endogenous ARID3A followed by LC-MS/MS
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025027 | Pride
Cmk Arid3a Ml-ds 
TranscriptomicsVitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) has been attributed to intrinsic resistance to chemotherapy and a growth-permissive tumor microenvironment. Quiescent pancreatic stellate cells (PSCs) are neuroendocrine, nestin-positive, lipid-accumulating cells whose homologues i...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-43770 | biostudies-arrayexpress
TranscriptomicsAn interferon-response induced by tumor-stroma interaction in a subset of human breast cancers
This SuperSeries is composed of the following subset Series: GSE7260: epithelial-mesenchymal interaction of the breast GSE7263: Effect of heterotypic interaction between breast cancer cell line MDA-MB231 and CCL-171 fibroblast Refer to individual Series
ORGANISM(S): Homo sapiens 
2007-11-13 | E-GEOD-7264 | biostudies-arrayexpress
Transcriptomicsepithelial-mesenchymal interaction of the breast
These 95 arrays are the basis for Figure 2 of our manuscript "An interferon-response induced by tumor-stroma interaction in a subset of human breast cancers". Abstract:Background Communication between different cell types is a cardinal feature of multi-cellular organisms and perturbations ...
ORGANISM(S): Homo sapiens 
2007-11-13 | E-GEOD-7260 | biostudies-arrayexpress
TranscriptomicsEffect of heterotypic interaction between breast cancer cell line MDA-MB231 and CCL-171 fibroblast
These 12 arrays are the basis for Figure 1 of the "An interferon-response induced by tumor-stroma interaction in a subset of human breast cancers" manuscript. Figure 1: Effect of heterotypic interaction between breast cancer cell line MDA-MB231 and CCL-171 fibroblast. Biologically indepen...
ORGANISM(S): Homo sapiens 
2007-11-13 | E-GEOD-7263 | biostudies-arrayexpress
TranscriptomicsSupervised Lowess normalization of comparative genome hybridization data: application to lactococcal strain comparisons.
Background Array-based comparative genome hybridization (aCGH) is commonly used to determine the genomic content of bacterial strains. In aCGH data, systematic errors are comparable to those occurring in transcriptome data. However, especially for microbes, an additional source of variation exists: ...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2008-07-19 | E-GEOD-9039 | biostudies-arrayexpress
GenomicsDivergent residues within histone H3 define a unique chromatin structure in S. cerevisiae
Histones are among the most conserved proteins known, but organismal differences do exist. In this study we examined the contribution that divergent amino acids within histone H3 make to cell growth and chromatin structure in S. cerevisiae. We show that, while amino acids that define histone H3.3 ar...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-10 | E-GEOD-73425 | biostudies-arrayexpress
GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites [S-phase/M-phase synchronized cells]
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51290 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs regulated by vitamin D within primary human osteoblasts
Identified a series of miRNAs transcriptionally regulated by vitamin D treatment within osteoblasts. Several miRNAs were validated in dose escalation experiments. Furthermore, downstream miRNA targets were appraised and found to regulate target message and protein levels. These findings were assesse...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-34144 | biostudies-arrayexpress
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