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GenomicsMurine ML-DS-like leukemias
Modelling the progression from TAM to ML-DS in children with Down syndrome utilizing a murine transplantation model
PRJEB30376 | ENA
GenomicsRNA sequencing data from Myeloid Leukaemia of Down Syndrome (ML-DS)
RNA sequencing data from Myeloid Leukaemia of Down Syndrome (ML-DS)
PRJEB32403 | ENA
TranscriptomicsRNA sequencing data from Myeloid Leukaemia of Down Syndrome (ML-DS)
Paired-end 150bp RNA sequencing data from ML-DS samples.
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-7932 | biostudies-arrayexpress
GenomicsTranscriptome analysis of cell line/patient-derived xenograft (PDX) samples of myeloid leukemia associated with Down syndrome (ML-DS)
Transcriptome analysis of cell line/patient-derived xenograft (PDX) samples of myeloid leukemia associated with Down syndrome (ML-DS)
PRJNA1130406 | ENA
ProteomicsCMK LC-MS/MS after CoIP of ARID3A
In order to determine proteins interacting with ARID3A in the ML-DS cell line CMK, we performed CoIP of endogenous ARID3A followed by LC-MS/MS
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025027 | Pride
Cmk Arid3a Ml-ds 
GenomicsExpression data of human mesenchymal stromal cells isolated from bone marrow of ML-DS, AMKL patients and HD
Expression data of human mesenchymal stromal cells isolated from bone marrow of ML-DS, AMKL patients and HD
PRJNA577634 | ENA
TranscriptomicsTranscriptome analysis of cell line/patient-derived xenograft (PDX) samples of myeloid leukemia associated with Down syndrome (ML-DS)
Myeloid leukemia associated with Down syndrome (ML-DS) is a rare pediatric cancer in which 10-20% patients who are relapsed/refractory have very limited treatment options. Novel treatment options may be identified via transcriptome profiling.
ORGANISM(S): Homo sapiens 
2026-06-18 | GSE271179 | GEO
TranscriptomicsExpression data of human mesenchymal stromal cells isolated from bone marrow of ML-DS, AMKL patients and HD
Bone marrow fibrosis (BMF) is a rare complication in acute leukemia. In pediatrics, it predominantly occurs in acute megakaryoblastic leukemia (AMKL) and here especially in patients with trisomy 21, called myeloid leukemia in Down syndrome (ML-DS). Defects in mesenchymal stromal cells (MSCs) and cyt...
ORGANISM(S): Homo sapiens 
2020-07-27 | GSE138861 | GEO
TranscriptomicsMultiplexed DNA high throughput genotyping study to determine the mutational status of transient (TAM) and acute myeloid leukaemic (ML-DS) Down syndrome individuals.
We used a 48.48 Fluidigm Access Array approach (1070 Amplicons spanning 62 genes: 157kB coverage) of genomic DNA from over 100 samples to genotype individuals with transient abnormal myelopoiesis (TAM) and acute myeloid leukemia of Down syndrome (ML-DS). Individually barcoded patient samples were ...
ORGANISM(S): Homo sapiens 
2019-07-17 | E-MTAB-7729 | biostudies-arrayexpress
UnknownCPX-351 in Down syndrome-associated myeloid leukemia: results and prognostic factors from the phase 3 ML-DS 2018 trial.
Not available
S-EPMC12824674 | biostudies-literature
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