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MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
Transcriptomicsdspa/e of erwinia amylovora-Regulation of the Arabidopsis transcriptome by the type three effector DspA/E of E...
ra06-03_dspa-erwinia - dspa/e of erwinia amylovora - Identification of Arabidopsis genes regulated by the type three effector Dspa/E of Erwinia amylovora. - Regulation of the Arabidopsis transcriptome by the type three effector DspA/E of Erwinia amylovora. 5-week old Arabidopsis plants were leaf inf...
ORGANISM(S): Arabidopsis thaliana 
2010-05-25 | E-GEOD-8436 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsMetabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor (Untargeted urine UPLC-MS assay)
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at non relevant doses or in combination with other r...
2019-05-28 | MTBLS596 | MetaboLights
TranscriptomicsProtein Kinase C Alpha Promotes Tumor Growth by Initiating a Feed-forward Network Involving miR-15a and Cyclin E
Protein Kinase C alpha (PKC) is associated with progression and poor prognosis in head and neck cancer. Previous studies have demonstrated that PKC sustains the proliferative signal by increasing cyclin E expression, leading to enhanced E2F target gene transcription and DNA synthesis. Here we show ...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-10301 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Escherichia coli O157:H7 (Sakai) in response to spinach leaf lysates by RNA-seq
E. coli O157:H7 can use vegetables such as spinach as secondary hosts, from where they can be transmitted into the food chain. Our previous microarray analysis showed whole-scale changes in gene expression of E. coli driven in a large part in response to plant metabolites. The aim of this work was t...
ORGANISM(S): Escherichia coli 
2018-12-13 | E-MTAB-7441 | biostudies-arrayexpress
TranscriptomicsDifferentially Expressed Genes between Drought-tolerant and Drought-sensitive Barley Genotypes
Drought tolerance is a key trait for increasing and stabilizing barley productivity in dry areas worldwide. Identification of the genes responsible for drought tolerance in barley (Hordeum vulgare L.) will facilitate understanding of the molecular mechanisms of drought tolerance, and also genetic im...
ORGANISM(S): Hordeum vulgare 
2009-05-13 | E-GEOD-15970 | biostudies-arrayexpress
MetabolomicsOnline Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept
This work introduces a novel online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted metabolomics approach, suggested as an alternative tool to study the environmental fate of volatile xenometabolites in emerging complex biopesticides, e.g. the Myrica gale ...
2021-01-26 | MTBLS2026 | MetaboLights
TranscriptomicsGEMM CRC collection analysis
A collection of genetically engineered mouse models (GEMM) of colorectal cancer (CRC) were created, and primary tumors from these GEMMs were analyzed. Primary CRC tumors from these GEMMs were genotyped to confirm that they contain the core genetic lesions of interest, including APC, P53, KRAS, and B...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-50794 | biostudies-arrayexpress
TranscriptomicsExpression data from genetically engineered mouse models (GEMMs)
3 Cell lines from Apc, p53 (AP) GEMMs were compared to 12 cell lines from Apc, Kras, p53 (AKP) GEMMs. Mouse 430 2.0 arrays were used to determine genomic expression differences between the two genotypes (AP and AKP). RNA was extracted from 3 AP and 10 AKP cell lines using the Qiagen RNEasy kit, and ...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-39557 | biostudies-arrayexpress
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