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MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
UnknownRole of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.
Not available
S-EPMC5015423 | biostudies-literature
UnknownDepression in working adults: comparing the costs and health outcomes of working when ill.
Not available
S-EPMC4152191 | biostudies-literature
TranscriptomicsDeregulated Myc expression induces addiction to AMPK-related kinase 5
U2OS cells were infected with shRNA vector targeting Ark5 or control vector, selected on puromycin for 48hrs, seeded on 5cm dishes at 20% confluency and harvested in triplicate 48hrs later
ORGANISM(S): Homo sapiens 
2012-03-01 | E-MEXP-3543 | biostudies-arrayexpress
OtherMass-spectrometry-based draft of the human proteome
Data from ProteomeXchange, PXD ID: PXD000865. File: 00645_A01_P004893_B0A_A00_R1.mzml. Published as part of Nature 509, 582-587, 29 May 2014.
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310000771 | GPMDB
Resource Reanalysis 
TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
TranscriptomicsGene expression of LNCaP cells grown in 2D cultures and polyethlene glycol-based hydrogels with the presence of synthetic androgen, R1881
Analysis of LNCaP cell molecular differences and their response to R1881 in 2D and 3D cultures. Androgen regulated genes were differentially expressed between 2D and 3D cultures. These results provide insights into factors that influence the expression of androgen regulated genes In this study, LNCa...
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-33610 | biostudies-arrayexpress
MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
ProteomicsMass spectrometry based draft of the human proteome
This PXD project contains two projects published on ProteomicsDB (https://www.proteomicsDB.org) as integral part of the publication. The first project entitled 'human body map' (https://www.proteomicsdb.org/#projects/42) involves the analysis of 36 different human tissues and body fluids. The second...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-23 | MSV000079526 | MassIVE
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
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