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GenomicsIn vivo T-box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuro-mesodermal Bipotency.
We defined genome-wide regulatory inputs of the T-box transcription factors Brachyury (Xbra), Eomesodermin (Eomes) and VegT that maintain neuro-mesodermal stem cells and determine their bipotential fates in the Xenopus tropicalis frog embryo. Binding profiles for Xbra, Eomes and VegT in X. tropicali...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2013-09-19 | E-GEOD-48560 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
UnknownInvestigation of split CoFeB/Ta/CoFeB/MgO stacks for magnetic memories applications.
Not available
S-EPMC7552826 | biostudies-literature
TranscriptomicsIn vivo T-box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuro-mesodermal Bipotency
Brachyury (Xbra/Xbra3) knock-down embryos of the frog Xenopus tropicalis were profiled to quantify neuro-mesodermal cell fate switches at a transcriptional level. Transcriptional profiling of Xbra/Xbra3 double morphants at early tadpole stage (RNA-Seq) in biological triplicates.
ORGANISM(S): Xenopus (Silurana) tropicalis 
2013-09-19 | E-GEOD-48663 | biostudies-arrayexpress
UnknownEmerging good practices for Translatability Assessment (TA) of Patient-Reported Outcome (PRO) measures.
Not available
S-EPMC5935017 | biostudies-literature
TranscriptomicsGene expression profiling of in vitro derived induced and natural FOXP3+ regulatory T cells and ex-iTreg cells in the mouse
Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTr...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35543 | biostudies-arrayexpress
UnknownComparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition.
Not available
S-EPMC9892865 | biostudies-literature
TranscriptomicsGene expression profiling of M0, M1 and M2a macrophages after 7 days of culture
The relative contribution of polarized macrophages to the maintenance of tolerance is unknown. We examined their roles by in vivo adoptive transfer immunotherapy of M0, M1 and M2a macrophages as pre-treatment of colitis. In other experiments, M2a macrophages were used as pre-treatment or treatment o...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-72518 | biostudies-arrayexpress
UnknownAttacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.
Not available
S-EPMC6922308 | biostudies-literature
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