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TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
TranscriptomicsFasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Short-term starvation (STS or fasting) provides protection to normal cells, mice, and possibly patients from a variety of chemotherapy drugs, but the possibility that it may also protect tumor cells renders its translational potential uncertain. Here we show that fasting cycles can be as effective a...
ORGANISM(S): Mus musculus 
2012-03-21 | E-GEOD-28556 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+ deacetylase, improves metabolism and confers protection against physiological and cognitive distur...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-50987 | biostudies-arrayexpress
TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
TranscriptomicsRegulation of ER Homeostasis and Cell Cycle by Pax4 Enhances β-Cell Survival and Protects Mice Against Experimental Autoimmune Diabetes
Strategies to enhance islet b-cell survival and regeneration while refraining inflammation through manipulation of molecular targets would provide means to stably replenish the deteriorating functional b-cell mass detected in both Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM). Herein we report...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-62846 | biostudies-arrayexpress
TranscriptomicsResveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat, high-sugar diet.
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and ...
ORGANISM(S): Macaca mulatta 
2014-04-21 | E-GEOD-50005 | biostudies-arrayexpress
TranscriptomicsDeletion of the Mammalian INDY Homologue in Mice Mimics Aspects of Dietary Restriction and Protects Against Diet and Age-Induced Adiposity and Insulin Resistance
Reduction in expression of the INDY gene in Drosophila melanogaster and Caenorhabditis elegans prolongs life span, and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which INDY does this is unknown. In order to examine...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-29984 | biostudies-arrayexpress
TranscriptomicsGrowth Hormone Receptor and IGF-I Deficiency is Associated with Resistance to DNA Damage and Very Low Cancer and Diabetes Incidence in Humans
Growth Hormone Receptor Deficiency (GHRD) in mice causes life span extension and a major increase in the portion of animals that die without detectable pathologies including cancer and insulin resistance. During a 22-year monitoring of a cohort of 0-88 year old Ecuadorian GHRD subjects with severe I...
ORGANISM(S): Homo sapiens 
2010-12-25 | E-GEOD-21980 | biostudies-arrayexpress
TranscriptomicsMetformin mild supplementation improves health and survival of mice
Metformin, a commonly used drug prescribed to treat type-2 diabetes, has been found to extend health span and delay cancer incidence and progression. Here, we report that starting chronic treatment with low dose of metformin (0.1% w/w in diet) at one year of age extends health and lifespan in male m...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-40936 | biostudies-arrayexpress
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