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ProteomicsO-GlcNAcylation and chaperonin CCT5 protect OTX2 from aggregation in medulloblastoma cellsO-GlcNAcylation andanalysis of OTX2 O-GlcNac sites and dependent interactions
In this study, we demonstrated that OTX2 was transcriptionally and post-transcriptionally regulated by O-GlcNAcylation. We describe the modes of degradation of this essential homeobox protein involving both the proteasome and macroautophagy. While the proteasome remains the canonical degradation pat...
ORGANISM(S): Homo sapiens (Human) 
2024-01-22 | PXD040353 | Pride
Otx2 Ethcd-ms O-glcnac Interactome 
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [RNA-Seq_Stability]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-77704 | biostudies-arrayexpress
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [RNA-Seq_human]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-77702 | biostudies-arrayexpress
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [RNA-Seq_mouse]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-77703 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stems cells grown in chemically defined medium supplemented with Activen and FGF or FGF2 and SB431542 to identify genes controlled by Activin/Nodal signalling
Human Embryonic Stem Cells (hESC) grown in chemically defined medium (CDM) supplemented with Activin and FGF were compared to hESCs grown for 48 hours in CDM supplemented with FGF2 and SB431542, an inhibitor of Activin/Nodal signalling. The objective of this experiment was to discover the identity o...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-MEXP-1741 | biostudies-arrayexpress
UnknownIdentification of an oncogenic network with prognostic and therapeutic value in prostate cancer
Not available
S-SCDT-86105_2_1532693665_jats | biostudies-other
GenomicGWAS of Preterm Birth

Preterm birth (PTB, born before 37 weeks of gestation) is a leading cause of neonatal mortality and post-natal morbidity. PTB affects one in nine all live births in the U.S. Notably, the highest rate of PTB occurs among African Americans (one in six). PTB is a complex trait, likely determined by ...

phs000332 | dbGaP
GenomicThe EVE Asthma Genetics Consortium: Building Upon GWAS

The EVE Asthma Genetics Consortium comprises U.S. investigators who have conducted genome-wide association studies (GWAS) of asthma; the main objective is to combine results of individual studies to increase the overall power to identify loci for asthma and asthma-associated traits. The consortiu...

phs001156 | dbGaP
TranscriptomicsDistinct and shared molecular targets and functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [CLIP-Seq]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-77700 | biostudies-arrayexpress
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [array]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-77699 | biostudies-arrayexpress
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