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UnknownAtherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.
Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque formation and the chance of cardiovascular events. Com...
S-EPMC10721632 | biostudies-literature
UnknownInflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation.
Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells. The anti-diabetic drug Metformin inhibits acute and chronic inflammation through mechanisms sti...
S-EPMC10656499 | biostudies-literature
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