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UnknownDietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice.
The leishmaniases are a group of diseases caused by Leishmania parasites, which have different clinical manifestations. Leishmania (Leishmania) amazonensis is endemic in South America and causes cutaneous leishmaniasis (CL), which can evolve into a diffuse form, characterized by an ane...
S-EPMC6467002 | biostudies-literature
UnknownEffects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by Leishmania amazonensis.
Cutaneous leishmaniasis remains both a public health and a therapeutic challenge. To date, no ideal therapy for cutaneous leishmaniasis has been identified, and no universally accepted therapeutic regimen and approved vaccines are available. Due to the mesenchymal stromal cell (MSC) immunomodulatory...
S-EPMC5554126 | biostudies-literature
Unknown<i>Crithidia fasciculata</i> Shows Non-Pathogenic Behavior in Leishmania Co-Infection Related to Temperature Stress, In Vitro and In Vivo Infections, and Amphotericin B Susceptibility.
There is increasing evidence on the occurrence of Crithidia spp. in patients presenting either cutaneous or visceral leishmaniasis, solely or associated with Leishmania. We analyzed growth, morphology, and temperature tolerance of two C. fasciculata strains, the reference strain...
S-EPMC12566015 | biostudies-literature
UnknownIsolation and characterization of vB_XciM_LucasX, a new jumbo phage that infects Xanthomonas citri and Xanthomonas fuscans.
Citrus canker is one of the main bacterial diseases that affect citrus crops and is caused by Xanthomonas citri which affects all citrus species worldwide. New strategies to control citrus canker are necessary and the use of bacteriophages as biocontrol agent could be an alternative. Phages that inf...
S-EPMC9009655 | biostudies-literature
UnknownA link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis.
Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mecha...
S-EPMC11059367 | biostudies-literature
UnknownProanthocyanidins with Corrosion Inhibition Activity for AISI 1020 Carbon Steel under Neutral pH Conditions of Coconut (Cocos nucifera L.) Husk Fibers.
Cocos nucifera L. is a palm tree (Arecaceae) with a high economic value. The coconut husk fibers are nonedible, thick, and abrasion-resistant and correspond up to 85% of biomass discarded as solid waste residue. Therefore, the husk fibers are an underexploited byproduct with a high content of...
S-EPMC7970558 | biostudies-literature
ProteomicsTrypanosomatid extracellular vesicles as potential immunogens in Chagas disease
Extracellular vesicles (EVs) from parasite protozoa can induce efficient immunity, which makes them useful for probable next-generation vaccines, more specifically against Trypanosoma cruzi infection. Howevver, the mechanisms involved in the protective responses have not been fully elucidated. To in...
ORGANISM(S): Trypanosoma rangeli Trypanosoma cruzi Dm28c Phytomonas serpens 
2025-01-21 | PXD040019 | Pride
Immunogens Trypanosomatid Extracellular vesicles Chagas disease 
UnknownEfficacy of LaAg Vaccine Associated with Saponin Against Leishmania amazonensis Infection.

Background/objectives

The total lysate of Leishmania amazonensis (LaAg) is one of the most extensively studied vaccine formulations against leishmaniasis. Despite demonstrating safety and immunogenicity when administered intramuscularly, LaAg has failed to show efficacy in clinical tr...
S-EPMC11861163 | biostudies-literature
UnknownGene Duplication in the Sugarcane Genome: A Case Study of Allele Interactions and Evolutionary Patterns in Two Genic Regions.
Sugarcane (Saccharum spp.) is highly polyploid and aneuploid. Modern cultivars are derived from hybridization between S. officinarum and S. spontaneum. This combination results in a genome exhibiting variable ploidy among different loci, a huge genome size (~10 Gb) and a high co...
S-EPMC6514446 | biostudies-literature
UnknownA Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location.
The search for antiprion compounds has been encouraged by the fact that transmissible spongiform encephalopathies (TSEs) share molecular mechanisms with more prevalent neurodegenerative pathologies, such as Parkinson's and Alzheimer's diseases. Cellular prion protein (PrPC) conversion int...
S-EPMC5786768 | biostudies-literature
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