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TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [SNP]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-39412 | biostudies-arrayexpress
TranscriptomicsATAC-seq analysis of ARID1A-deficient TOV112D human ovarian cancer cells treated with the G9a inhibitor BIX01294
Biological relevance: This study aims to evaluate how G9a inhibition via BIX01294 affects the chromatin landscape in the context of ARID1A deficiency. We investigated whether the loss of the SWI/SNF subunit ARID1A alters the cellular response to G9a pharmacological targeting in ovarian cancer. Expe...
ORGANISM(S): Homo sapiens 
2026-03-20 | E-MTAB-16777 | biostudies-arrayexpress
TranscriptomicsAltered antisense-to-sense transcript ratios in breast cancer: Agilent
Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-26000 | biostudies-arrayexpress
TranscriptomicsAltered antisense-to-sense transcript ratios in breast cancer: ASSAGE
Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-25932 | biostudies-arrayexpress
TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [RNA-Seq]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-69114 | biostudies-arrayexpress
TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [methylation450]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-67619 | biostudies-arrayexpress
TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [methylation27]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-38791 | biostudies-arrayexpress
GenomicsEpigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [ChIP-Seq]
Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylati...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26137 | biostudies-arrayexpress
TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [DGE]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-38790 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human tissue samples using SAGE-Seq
We present a powerful application of ultra high-throughput sequencing, SAGE-Seq, for the accurate quantification of normal and neoplastic mammary epithelial cell transcriptomes. We develop data analysis pipelines that allow the mapping of sense and antisense strands of mitochondrial and RefSeq genes...
ORGANISM(S): Homo sapiens 
2010-10-05 | E-GEOD-24491 | biostudies-arrayexpress
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