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ProteomicsDiadenosine tetraphosphate as a cosubstrate for AMPylation mediated by FICD
Diadenosine polyphosphates (ApnAs) are noncanonical nucleotides that are ubiquitous across all forms of life. Due to their strong accumulation upon cellular stress, they are considered alarmones to signal homeostatic imbalance. Nonetheless, their cellular role is poorly understood. In this work, we ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-27 | PXD036450 | Pride
Diadenosine tetraphosphate Ampylation Ficd Post-translational modification Proteomics 
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
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