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ProteomicsDiadenosine tetraphosphate as a cosubstrate for AMPylation mediated by FICD
Diadenosine polyphosphates (ApnAs) are noncanonical nucleotides that are ubiquitous across all forms of life. Due to their strong accumulation upon cellular stress, they are considered alarmones to signal homeostatic imbalance. Nonetheless, their cellular role is poorly understood. In this work, we a...
ORGANISM(S): Homo sapiens (Human) 
2023-01-27 | PXD036450 | Pride
Diadenosine tetraphosphate Ampylation Ficd Post-translational modification Proteomics 
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MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, we...

2022-10-03 | MTBLS4497 | MetaboLights
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UnknownCombined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies.
Not available
S-EPMC4494917 | biostudies-literature
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UnknownApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Not available
S-EPMC9422774 | biostudies-literature
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UnknownChemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.
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S-EPMC4636490 | biostudies-literature
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UnknownComparison of different scoring methods based on latent variable models of the PHQ-9: an individual participant data meta-analysis.
Not available
S-EPMC9393567 | biostudies-literature
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UnknownData-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.
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S-EPMC11584932 | biostudies-literature
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UnknownAccuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis.
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S-EPMC8491108 | biostudies-literature
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UnknownMulti-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.
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S-EPMC9925385 | biostudies-literature
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UnknownIdentification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.
Not available
S-EPMC9857322 | biostudies-literature
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