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TranscriptomicsT. Brucei, Nup-1 Depletion
Organization of the genome into compacted chromatin is a eukaryotic innovation facilitating increased sophistication in transcriptional regulation. In metazoa coiled-coil lamin proteins are major components of the chromatin organizer at the nuclear periphery and maintain nuclear integrity. While ide...
ORGANISM(S): Trypanosoma brucei 
2011-12-15 | E-GEOD-26256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and ATF3 -/-mouse bone marrow macrophages stimulated with lipopolysaccharide for 1, 2, 4, 8 and 24 hours
Time course data from lipopolysaccharide-stimulated wild-type and ATF3 -/- mouse bone marrow macrophages were collected to investigate the transcriptional network in Toll-like recepter 4-activated macrophages.
ORGANISM(S): Mus musculus 
2006-06-08 | E-TABM-102 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow-derived macrophages simulated with LPS, time series
The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interp...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-14769 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, a...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6376 | biostudies-arrayexpress
TranscriptomicsProfiling 20,077 genes in 25 vaccine recipients: U133 Plus 2.0, Custom CDF Version 9
The immune responses generated by YF-17D by profiling 20,077 genes in 25 vaccine recipients were accessed at days 1, 3, 7, and 21 post-vaccination compared to pre-vaccination in PBMCs. The immune responses generated by YF-17D by profiling 20,077 genes in 25 vaccine recipients were accessed at days ...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-13485 | biostudies-arrayexpress
TranscriptomicsProfiling 11,639 genes in PBMCs from 2 donors: U133 A 2.0 Custom CDF Version 9
The immune responses generated by YF-17D by profiling 11,639 genes in PBMCs from 2 donors cultured with YF-17D vaccine were accessed after 3 and 12 hours. Keywords: time course, in vitro stimulaion PMBCs were isolated with citrate buffered cell preparation tubes (CPT) from 2 healthy donors who were...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-13484 | biostudies-arrayexpress
TranscriptomicsHalobacterium salinarum NRC-1 growth curve, tiling arrays
Experimentally mapped transcriptome structure of H. salinarum NRC-1 by hybridizing total RNA (including RNA species <200 nt) to genome-wide high-density tiling arrays (60 mer probes with 40 nt overlap between contiguous probes). H. salinarum NRC-1 presents a number of interesting switches in metabol...
ORGANISM(S): Halobacterium sp. NRC-1 
2010-05-17 | E-GEOD-12923 | biostudies-arrayexpress
no omics definedChromatin immunoprecipitation of ATF3-/- mouse bone marrow macrophages with and without stimulation with lipopolysaccharide for 1 or 2 hours
DNA binding determination for ATF3 -/- macrophages without stimulation and with stimulation by LPS after 1 or 2 hours.
ORGANISM(S): Mus musculus 
2006-07-07 | E-MEXP-730 | biostudies-arrayexpress
TranscriptomicsYeast (Saccharomyces cerevisiae) Overexpression suppression study
To address the mechanisms of suppression, we analyzed time course of mRNA expression of four suppressed smc2-8 mutant strains. We addressed the question of genomic robustness by systematically screening genomic open reading frames, when induced for high-level expression, for their ability to suppres...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-20 | E-GEOD-24266 | biostudies-arrayexpress
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