T. Brucei, Nup-1 Depletion

ABSTRACT: Organization of the genome into compacted chromatin is a eukaryotic innovation facilitating increased sophistication in transcriptional regulation. In metazoa coiled-coil lamin proteins are major components of the chromatin organizer at the nuclear periphery and maintain nuclear integrity. While identifiable lamin homologues are restricted to metazoans, morphologically analogous structures maintaining nuclear organization in other eukaryotic lineages are known, but the molecular constituents remain undefined. Trypanosoma brucei NUP-1 is a large coiled-coil protein associated with fibrils at the inner face of the nuclear envelope. Using transcriptome analysis in combination with RNA interference and various imaging techniques, we demonstrate that NUP-1 forms a stable immobile cage around th

ORGANISM(S): Trypanosoma brucei

SUBMITTER: Bruz Marzolf 

PROVIDER: E-GEOD-26256 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress