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Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
Metabolomics1H HR-MAS NMR based metabolomics of cancer cells responding to two different doses of the diruthenium trithiolato complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1)
The trithiolato bridged diruthenium complex DiRu-1 [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ is highly cytotoxic against various cancer cell lines, but its exact mode of action remained unknown. The present 1H HR-MAS NMR based metabolomic study performed on the ovarian cancer cell lines A2780, its cisPt re...
2019-07-04 | MTBLS1014 | MetaboLights
TranscriptomicsTranscription profiling of neutrophils exposed to S. aureus infection
Neutrophil lysis after phagocytosis is a process potentially important in the pathogenesis of community-associated methicillin-resistant S. aureus (CA-MRSA) infection. The mechanism for this process is not currently known. Therefore, to better understand CA-MRSA virulence we used human oligonucleo...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-16837 | biostudies-arrayexpress
TranscriptomicsDynamics of two oscillation phenotypes in S. cerevisiae reveal a network of genome-wide transcriptional and cell cycle oscillators.
This SuperSeries is composed of the following subset Series: GSE30051: Dynamics of two oscillation phenotypes in S. cerevisiae[2hr] GSE30052: Dynamics of two oscillation phenotypes in S. cerevisiae[4hr]. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-30053 | biostudies-arrayexpress
TranscriptomicsS. aureus gene expression of WT (USA300) vs fakAKO
S. aureus response to fakA deletion Gene expression profiles were generated by microarray analysis of S. aureus WT (USA300) or fakAKO S. aureus was grown in LB to an OD600nm of 0.45, and RNA was extracted to look at the gobal gene expression.
ORGANISM(S): Staphylococcus aureus 
2014-08-01 | E-GEOD-57340 | biostudies-arrayexpress
TranscriptomicsS. aureus gene expression following AFN-1252 treatment
AFN-1252 is an inhibitor of fatty acid biosynthesis. Gene expression profiles were generated by microarray analysis of S. aureus cells following treatment with AFN-1252, an inhibitor of fatty acid synthesis. Fatty acid biosynthesis in S. aureus was inhibited by AFN-1252 for 15 minutes, and RNA was e...
ORGANISM(S): Staphylococcus aureus 
2010-07-29 | E-GEOD-19400 | biostudies-arrayexpress
UnknownReorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S-Adenosylmethionine Methyltransferase Reaction.
Not available
S-EPMC5870839 | biostudies-literature
TranscriptomicsS. aureus gene expression following growth in media containing oleic acid
S. aureus response to exogenous fatty acid (oleic acid) Gene expression profiles were generated by microarray analysis of S. aureus cells grown in media without or with oleic aicd Comparison of expression profiles after growth of S. aureus in exogenous fatty acid S. aureus was grown in media with an...
ORGANISM(S): Staphylococcus aureus subsp. aureus RN4220 
2012-12-21 | E-GEOD-36231 | biostudies-arrayexpress
TranscriptomicsExpression data from S. cerevisiae
Low level of H3 Lys4 tri-methylation is a signature feature of silenced chromatin regions. We used microarray to analyze the contribution of S. cerevisiae H3 Lys4 demethylase Jhd2p in silenced chromatin formation process. Total RNA from two JHD2 gene altered strains : jhd2 deletion and JHD2 over-ex...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-33077 | biostudies-arrayexpress
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